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Molecules 2018, 23(6), 1431; https://doi.org/10.3390/molecules23061431

Antischistosomal Properties of Hederacolchiside A1 Isolated from Pulsatilla chinensis

1
Department of Pharmacognosy, College of Pharmaceutical Science, Soochow University, Suzhou 215123, China
2
College of Pharmaceutical Science, Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, China
3
College of Pharmacy, Guangxi University of Chinese Medicine, Nanning 530001, China
4
Department of Pharmacology, College of Pharmaceutical Science, Soochow University, Suzhou 215123, China
5
Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala 75105, Sweden
*
Authors to whom correspondence should be addressed.
Received: 3 May 2018 / Revised: 31 May 2018 / Accepted: 9 June 2018 / Published: 13 June 2018
(This article belongs to the Special Issue Drug Discovery for Neglected Diseases)
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Abstract

Background: Schistosomiasis is a major neglected disease for which the current control strategy involves mass treatment with praziquantel, the only available drug. Hence, there is an urgent need to develop new antischistosomal compounds. Methods: The antischistosomal activity of hederacolchiside A1 (HSA) were determined by total or female worm burden reductions in mice harboring Schistosoma japonicum or S. mansoni. Pathology parameters were detected on HSA against 1-day-old S. japonicum-harboring mice. Moreover, we confirmed the antischistosomal effect of HSA on newly transformed schistosomula (NTS) of S. japonicum in vitro. Results: HSA, a natural product isolated from Pulsatilla chinensis (Bunge) Regel, was initially corroborated to possess promising antischistosomal properties. We demonstrated that HSA had high activity against S. japonicum and S. mansoni less in 11 days old parasites harbored in mice. The antischistosomal effect was even more than the currently used drugs, praziquantel, and artesunate. Furthermore, HSA could ameliorate the pathology parameters in mice harboring 1-day-old juvenile S. japonicum. We also confirmed that HSA-mediated antischistosomal activity is partly due to the morphological changes in the tegument system when NTS are exposed to HSA. Conclusions: HSA may have great potential to be an antischistosomal agent for further research. View Full-Text
Keywords: hederacolchiside A1; Schistosoma japonicum; Schistosoma mansoni; antischistosomal hederacolchiside A1; Schistosoma japonicum; Schistosoma mansoni; antischistosomal
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Kang, N.; Shen, W.; Gao, H.; Feng, Y.; Zhu, W.; Yang, S.; Liu, Y.; Xu, Q.; Yu, D. Antischistosomal Properties of Hederacolchiside A1 Isolated from Pulsatilla chinensis. Molecules 2018, 23, 1431.

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