Next Article in Journal
Monohexosylceramides from Rhizopus Species Isolated from Brazilian Caatinga: Chemical Characterization and Evaluation of Their Anti-Biofilm and Antibacterial Activities
Next Article in Special Issue
Cu(II) Complexes of 4-[(1E)-N-{2-[(Z)-Benzylidene-amino]ethyl}ethanimidoyl]benzene-1,3-diol Schiff Base: Synthesis, Spectroscopic, In-Vitro Antioxidant, Antifungal and Antibacterial Studies
Previous Article in Journal
Red and Blue Light Promote the Accumulation of Artemisinin in Artemisia annua L.
Previous Article in Special Issue
Dicyanamide Bridged Cu(II)36-Metallacrown-6 Complex with 1,4,7-Triisopropyl-1,4,7-Triazacyclononane and Binding Properties with DNA
Article Menu
Issue 6 (June) cover image

Export Article

Open AccessArticle

Detection and Identification of Estrogen Based on Surface-Enhanced Resonance Raman Scattering (SERRS)

College of Physics, Jilin Normal University, Siping 136000, China
Key Laboratory of Functional Materials Physics and Chemistry of the Ministry of Education, Jilin Normal University, Changchun 130103, China
School of Electronic and Information Engineering, South China University of Technology, Guangzhou 510640, China
Department of Chemistry, Institute for Molecular Science and Fusion Technology, Kangwon National University, Chunchon 24341, Korea
Authors to whom correspondence should be addressed.
Molecules 2018, 23(6), 1330;
Received: 25 April 2018 / Revised: 28 May 2018 / Accepted: 31 May 2018 / Published: 1 June 2018
(This article belongs to the Special Issue Metal Complexes of Biological Ligands)
PDF [14719 KB, uploaded 6 June 2018]


Many studies have shown that it is important to consider the harmful effects of phenolic hormones on the human body. Traditional UV detection has many limitations, so there is a need to develop new detection methods. We demonstrated a simple and rapid surface-enhanced resonance Raman scattering (SERRS) based detection method of trace amounts of phenolic estrogen. As a result of the coupling reaction, there is the formation of strong SERRS activity of azo compound. Therefore, the detection limits are as low as 0.2 × 10−4 for estrone (E1), estriol (E3), and bisphenol A (BPA). This method is universal because each SERRS fingerprint of the azo dyes a specific hormone. The use of this method is applicable for the testing of phenolic hormones through coupling reactions, and the investigation of other phenolic molecules. Therefore, this new method can be used for efficient detection. View Full-Text
Keywords: phenolic hormones; SERRS; detection phenolic hormones; SERRS; detection

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material


Share & Cite This Article

MDPI and ACS Style

Liu, Y.; Chen, Y.; Zhang, Y.; Kou, Q.; Zhang, Y.; Wang, Y.; Chen, L.; Sun, Y.; Zhang, H.; Jung, Y.M. Detection and Identification of Estrogen Based on Surface-Enhanced Resonance Raman Scattering (SERRS). Molecules 2018, 23, 1330.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top