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Molecules 2018, 23(6), 1298;

The Selectivity of Polymers Imprinted with Amines

Department of Inorganic and Analytical Chemistry, Budapest University of Technology and Economics, Szent Gellert ter 4., H-1111 Budapest, Hungary
MTA-BME Research Group of Technical Analytical Chemistry, Szent Gellert ter 4., H-1111 Budapest, Hungary
Authors to whom correspondence should be addressed.
Received: 8 May 2018 / Revised: 18 May 2018 / Accepted: 24 May 2018 / Published: 29 May 2018
(This article belongs to the Special Issue Synthesis and Applications of Molecularly Imprinted Polymers)
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One of the main reasons for making molecularly imprinted polymers (MIPs) has been that MIPs interact selectively with a specific target compound. This claim is investigated here with the example of a widely used type of noncovalent MIP, the MIP for the beta blocker propranolol. Adsorption isotherms of this MIP and of a nonimprinted control polymer (NIP), respectively, have been measured with a series of compounds in the porogen solvent acetonitrile. The results, visualized as “selectivity ladders”, show that the MIP binds propranolol and many other amines better than the NIP does, but the selectivity of the MIP is actually inferior to that of the NIP. The selectivity of either polymer for propranolol is modest against many amines, but is remarkable with respect to other compounds. The contribution of imprinting towards selectivity can be better appreciated when three MIPs, made with different amine templates, are compared among themselves. Each MIP is seen to bind its own template slightly better than the other two MIPs do. In media different from the porogen, the selectivity patterns may change substantially. Propranolol seems to have properties that make it stand high on the selectivity scale in different solvents, albeit for different reasons. View Full-Text
Keywords: molecular imprinting; selectivity ladder; adsorption; beta blocker; medium effect molecular imprinting; selectivity ladder; adsorption; beta blocker; medium effect

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Dorkó, Z.; Nagy-Szakolczai, A.; Tóth, B.; Horvai, G. The Selectivity of Polymers Imprinted with Amines. Molecules 2018, 23, 1298.

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