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Molecules 2018, 23(6), 1265;

Whole Cells as Biocatalysts in Organic Transformations

Laboratory of Organic Synthesis Bio- and Organocatalysis, Chemistry Department, Universidad de los Andes, Cra. 1No 18A-12 Q:305, Bogotá 111711, Colombia
Author to whom correspondence should be addressed.
Received: 8 April 2018 / Revised: 21 May 2018 / Accepted: 22 May 2018 / Published: 25 May 2018
(This article belongs to the Special Issue Enantioselective Catalysis)


Currently, the power and usefulness of biocatalysis in organic synthesis is undeniable, mainly due to the very high enantiomeric excess reached using enzymes, in an attempt to emulate natural processes. However, the use of isolated enzymes has some significant drawbacks, the most important of which is cost. The use of whole cells has emerged as a useful strategy with several advantages over isolated enzymes; for this reason, modern research in this field is increasing, and various reports have been published recently. This review surveys the most recent developments in the enantioselective reduction of carbon-carbon double bonds and prochiral ketones and the oxidation of prochiral sulfides using whole cells as biocatalytic systems. View Full-Text
Keywords: biocatalysis; whole cells; enantioselective transformations biocatalysis; whole cells; enantioselective transformations

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Garzón-Posse, F.; Becerra-Figueroa, L.; Hernández-Arias, J.; Gamba-Sánchez, D. Whole Cells as Biocatalysts in Organic Transformations. Molecules 2018, 23, 1265.

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