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Molecules 2018, 23(5), 986; https://doi.org/10.3390/molecules23050986

Antioxidative, Antiproliferative and Antimicrobial Activities of Phenolic Compounds from Three Myrcia Species

1
Department of Biological Sciences, Faculty of Sciences and Letters, University of São Paulo State (UNESP), Assis 19806-900, Brazil
2
ThoMSon Mass Spectrometry Laboratory, Institute of Chemistry, University of Campinas (UNICAMP), Campinas 13083-970, Brazil
3
Department of Botany, Institute of Biosciences of Botucatu, UNESP—Univ. Estadual Paulista, Botucatu 18618-970, Brazil
4
Faculty of Pharmaceutical Sciences, University of Campinas (UNICAMP) P.O. Box 859, Campinas 13083-859, Brazil
5
CPQBA, Microbiology Division, P.O. Box 6171, University of Campinas, Campinas 13083-970, Brazil
*
Author to whom correspondence should be addressed.
Received: 21 February 2018 / Revised: 24 March 2018 / Accepted: 29 March 2018 / Published: 24 April 2018
(This article belongs to the Section Natural Products Chemistry)
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Abstract

Myrcia bella Cambess., Myrcia fallax (Rich.) DC. and Myrcia guianensis (Aubl.) DC. (Myrtaceae) are trees found in Brazilian Cerrado. They have been widely used in folk medicine for the treatment of gastrointestinal disorders, hemorrhagic and infectious diseases. Few reports have been found in the literature connecting their phenolic composition and biological activities. In this regard, we have profiled the main phenolic constituents of Myrcia spp. leaves extracts by ESI(−)Q-TOF-MS. The main constituents found were ellagic acid (M. bella), galloyl glucose isomers (M. guianensis) and hexahydroxydiphenic (HHDP) acid derivatives (M. fallax). In addition, quercetin and myricetin derivatives were also found in all Myrcia spp. extracts. The most promising antioxidant activity, measured by 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity, was found for M. fallax extracts (EC50 8.61 ± 0.22 µg·mL−1), being slightly less active than quercetin and gallic acid (EC50 2.96 ± 0.17 and 2.03 ± 0.02 µg·mL−1, respectively). For in vitro antiproliferative activity, M. guianensis showed good activity against leukemia (K562 TGI = 7.45 µg·mL−1). The best antimicrobial activity was observed for M. bella and M. fallax to Escherichia coli (300 and 250 µg·mL−1, respectively). In conclusion, the activities found are closely related to the phenolic composition of these plants. View Full-Text
Keywords: Myrcia spp.; phenolic compounds; biological activities; ESI(−)Q-TOF-MS Myrcia spp.; phenolic compounds; biological activities; ESI(−)Q-TOF-MS
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Dos Santos, C.; Galaverna, R.S.; Angolini, C.F.F.; Nunes, V.V.A.; De Almeida, L.F.R.; Ruiz, A.L.T.G.; De Carvalho, J.E.; Duarte, R.M.T.; Duarte, M.C.T.; Eberlin, M.N. Antioxidative, Antiproliferative and Antimicrobial Activities of Phenolic Compounds from Three Myrcia Species. Molecules 2018, 23, 986.

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