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Molecules 2018, 23(4), 959; https://doi.org/10.3390/molecules23040959

Using Peptidomimetics and Constrained Peptides as Valuable Tools for Inhibiting Protein–Protein Interactions

Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
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Received: 27 March 2018 / Revised: 16 April 2018 / Accepted: 18 April 2018 / Published: 19 April 2018
(This article belongs to the Special Issue Protein-Protein Interactions)
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Abstract

Protein–protein interactions (PPIs) are tremendously important for the function of many biological processes. However, because of the structure of many protein–protein interfaces (flat, featureless and relatively large), they have largely been overlooked as potential drug targets. In this review, we highlight the current tools used to study the molecular recognition of PPIs through the use of different peptidomimetics, from small molecules and scaffolds to peptides. Then, we focus on constrained peptides, and in particular, ways to constrain α-helices through stapling using both one- and two-component techniques. View Full-Text
Keywords: protein–protein interactions; peptidomimetics; proteomimetics; macrocycles; stapled peptides protein–protein interactions; peptidomimetics; proteomimetics; macrocycles; stapled peptides
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Robertson, N.S.; Spring, D.R. Using Peptidomimetics and Constrained Peptides as Valuable Tools for Inhibiting Protein–Protein Interactions. Molecules 2018, 23, 959.

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