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Molecules 2018, 23(4), 834; https://doi.org/10.3390/molecules23040834

Fungal Metabolites Antagonists towards Plant Pests and Human Pathogens: Structure-Activity Relationship Studies

Dipartimento di Scienze Chimiche, Università di Napoli Federico II, Complesso Universitario Monte Sant’Angelo, Via Cintia 4, 80126 Napoli, Italy
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Received: 5 March 2018 / Revised: 29 March 2018 / Accepted: 2 April 2018 / Published: 5 April 2018
(This article belongs to the Special Issue Structure-Activity Relationship of Natural Products 2018)

Abstract

Fungi are able to produce many bioactive secondary metabolites that belong to different classes of natural compounds. Some of these compounds have been selected for their antagonism against pests and human pathogens and structure–activity relationship (SAR) studies have been performed to better understand which structural features are essential for the biological activity. In some cases, these studies allowed for the obtaining of hemisynthetic derivatives with increased selectivity and stability in respect to the natural products as well as reduced toxicity in view of their potential practical applications. This review deals with the SAR studies performed on fungal metabolites with potential fungicidal, bactericidal, insecticidal, and herbicidal activities from 1990 to the present (beginning of 2018). View Full-Text
Keywords: fungal secondary metabolites; bioactive natural products; fungicides; bactericides; insecticides; herbicides; SAR studies fungal secondary metabolites; bioactive natural products; fungicides; bactericides; insecticides; herbicides; SAR studies
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Masi, M.; Nocera, P.; Reveglia, P.; Cimmino, A.; Evidente, A. Fungal Metabolites Antagonists towards Plant Pests and Human Pathogens: Structure-Activity Relationship Studies. Molecules 2018, 23, 834.

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