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Review

Role of Plant-Derived Flavonoids and Their Mechanism in Attenuation of Alzheimer’s and Parkinson’s Diseases: An Update of Recent Data

1
Department of Physiology, Faculty of Life Sciences, Government College University, Faisalabad 38000, Pakistan
2
Center for Precision Medicine, School of Medicine and School of Biomedical Sciences, Huaqiao University, Xiamen 361021, China
3
Department of Zoology, Faculty of Life Sciences, Government College University, Faisalabad 38000, Pakistan
4
Department of Biosciences, COMSATS Institute of Information Technology, Islamabad 44000, Pakistan
*
Authors to whom correspondence should be addressed.
Molecules 2018, 23(4), 814; https://doi.org/10.3390/molecules23040814
Received: 19 February 2018 / Revised: 25 March 2018 / Accepted: 27 March 2018 / Published: 2 April 2018
(This article belongs to the Section Natural Products Chemistry)
Neurodegeneration is a progressive loss of neuronal cells in certain regions of the brain. Most of the neurodegenerative disorders (NDDs) share the communal characteristic such as damage or reduction of various cell types typically including astrocytes and microglial activity. Several compounds are being trialed to treat NDDs but they possess solitary symptomatic advantages along with copious side effects. The finding of more enthralling and captivating compounds to suspend and standstill the pathology of NDDs will be considered as a hallmark of present times. Phytochemicals possess the potential to alternate the synthetic line of therapy against NDDs. The present review explores the potential efficacy of plant-derived flavonoids against most common NDDs including Alzheimer’s disease (AD) and Parkinson’s disease (PD). Flavonoids are biologically active phytochemicals which possess potential pharmacological effects, including antiviral, anti-allergic, antiplatelet, anti-inflammatory, anti-tumor, anti-apoptotic and anti-oxidant effects and are able to attenuate the pathology of various NDDs through down-regulating the nitric oxide (NO) production, by reducing the tumor necrosis factor-α (TNF-α), by reducing the excitotoxicity of superoxide as well as acting as tyrosine kinase (TK) and monoamine oxidase (MAO) inhibiting enzyme. View Full-Text
Keywords: flavonoids; natural compounds; biomolecules; neurodegenerative diseases; nitric oxide; tumor necrosis factor-α; tyrosine kinase; monoamine oxidase flavonoids; natural compounds; biomolecules; neurodegenerative diseases; nitric oxide; tumor necrosis factor-α; tyrosine kinase; monoamine oxidase
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MDPI and ACS Style

Hussain, G.; Zhang, L.; Rasul, A.; Anwar, H.; Sohail, M.U.; Razzaq, A.; Aziz, N.; Shabbir, A.; Ali, M.; Sun, T. Role of Plant-Derived Flavonoids and Their Mechanism in Attenuation of Alzheimer’s and Parkinson’s Diseases: An Update of Recent Data. Molecules 2018, 23, 814. https://doi.org/10.3390/molecules23040814

AMA Style

Hussain G, Zhang L, Rasul A, Anwar H, Sohail MU, Razzaq A, Aziz N, Shabbir A, Ali M, Sun T. Role of Plant-Derived Flavonoids and Their Mechanism in Attenuation of Alzheimer’s and Parkinson’s Diseases: An Update of Recent Data. Molecules. 2018; 23(4):814. https://doi.org/10.3390/molecules23040814

Chicago/Turabian Style

Hussain, Ghulam, Longbin Zhang, Azhar Rasul, Haseeb Anwar, Muhammad U. Sohail, Aroona Razzaq, Nimra Aziz, Asghar Shabbir, Muhammad Ali, and Tao Sun. 2018. "Role of Plant-Derived Flavonoids and Their Mechanism in Attenuation of Alzheimer’s and Parkinson’s Diseases: An Update of Recent Data" Molecules 23, no. 4: 814. https://doi.org/10.3390/molecules23040814

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