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Two New Anisic Acid Derivatives from Endophytic Fungus Rhizopycnis vagum Nitaf22 and Their Antibacterial Activity

Department of Plant Pathology, College of Plant Protection, China Agricultural University, Beijing 100193, China
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Author to whom correspondence should be addressed.
Molecules 2018, 23(3), 591; https://doi.org/10.3390/molecules23030591
Received: 26 February 2018 / Revised: 3 March 2018 / Accepted: 4 March 2018 / Published: 6 March 2018
(This article belongs to the Section Natural Products Chemistry)
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Abstract

Rhizopycnis acids A (1) and B (2), two new anisic acid derivatives, were obtained from the ethyl acetate extract of the fermentation cultures of Rhizopycnis vagum, an endophytic fungus isolated from the healthy tissues of Nicotiana tabacum. The structures of the two compounds were determined through a series of 1D and 2D NMR and HRMS spectral analyses. Both compounds were the first anisic acid derivatives containing methylbutanoic/methylbutenoic acid group found in fungi. 1 and 2 displayed antibacterial activity against six tested bacteria with IC50 values in the range 16.1~81.3 μg/mL. View Full-Text
Keywords: endophytic fungus; Rhizopycnis vagum; anisic acid derivatives; rhizopycnis acids A and B; antibacterial activity endophytic fungus; Rhizopycnis vagum; anisic acid derivatives; rhizopycnis acids A and B; antibacterial activity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Wang, A.; Li, P.; Zhang, X.; Han, P.; Lai, D.; Zhou, L. Two New Anisic Acid Derivatives from Endophytic Fungus Rhizopycnis vagum Nitaf22 and Their Antibacterial Activity. Molecules 2018, 23, 591.

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