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Molecules 2018, 23(12), 3239; https://doi.org/10.3390/molecules23123239

Novel Terpenoids with Potent Cytotoxic Activities from Resina Commiphora

1
School of Chemical Science and Technology, Yunnan University, Kunming 650091, China
2
Guangdong Key Laboratory for Genome Stability & Disease Prevention, School of Pharmaceutical Sciences, Shenzhen University Health Science Center, Shenzhen 518060, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 23 November 2018 / Revised: 4 December 2018 / Accepted: 6 December 2018 / Published: 7 December 2018
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Abstract

A novel sesquiterpene dimer, spirocommiphorfuran A (1); two new cadinane sesquiterpenoids, commiphorenes A (2) and B (3); along with three known terpenoids (46), were isolated from Resina Commiphora. The structures of these new compounds were characterized by NMR, HRESIMS, quantum chemical computation, and X-ray diffraction analysis. Compound 1 features a 7-oxabicyclo[2.2.1]heptane-2-ene core, representing the first example of germacrane-type sesquiterpene dimer fused via a spiro ring system. Compound 2 is a novel sesquiterpene with a completely new carbon skeleton, which is characteristic of an additional carbon attaching to the cadinane backbone via a carbon–carbon bond. Additionally, compounds 2 and 4 exert acceptable cytotoxicity toward normal cells and high selectivity in cancer cells, especially in HepG2 cells. View Full-Text
Keywords: Resina Commiphora; terpenoids; X-ray; quantum chemical computation; cytotoxic activities Resina Commiphora; terpenoids; X-ray; quantum chemical computation; cytotoxic activities
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Hu, B.-Y.; Qin, D.-P.; Wang, S.-X.; Qi, J.-J.; Cheng, Y.-X. Novel Terpenoids with Potent Cytotoxic Activities from Resina Commiphora. Molecules 2018, 23, 3239.

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