Novel Terpenoids with Potent Cytotoxic Activities from Resina Commiphora
AbstractA novel sesquiterpene dimer, spirocommiphorfuran A (1); two new cadinane sesquiterpenoids, commiphorenes A (2) and B (3); along with three known terpenoids (4–6), were isolated from Resina Commiphora. The structures of these new compounds were characterized by NMR, HRESIMS, quantum chemical computation, and X-ray diffraction analysis. Compound 1 features a 7-oxabicyclo[2.2.1]heptane-2-ene core, representing the first example of germacrane-type sesquiterpene dimer fused via a spiro ring system. Compound 2 is a novel sesquiterpene with a completely new carbon skeleton, which is characteristic of an additional carbon attaching to the cadinane backbone via a carbon–carbon bond. Additionally, compounds 2 and 4 exert acceptable cytotoxicity toward normal cells and high selectivity in cancer cells, especially in HepG2 cells. View Full-Text
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Hu, B.-Y.; Qin, D.-P.; Wang, S.-X.; Qi, J.-J.; Cheng, Y.-X. Novel Terpenoids with Potent Cytotoxic Activities from Resina Commiphora. Molecules 2018, 23, 3239.
Hu B-Y, Qin D-P, Wang S-X, Qi J-J, Cheng Y-X. Novel Terpenoids with Potent Cytotoxic Activities from Resina Commiphora. Molecules. 2018; 23(12):3239.Chicago/Turabian Style
Hu, Bin-Yuan; Qin, Da-Peng; Wang, Shao-Xiang; Qi, Jing-Jing; Cheng, Yong-Xian. 2018. "Novel Terpenoids with Potent Cytotoxic Activities from Resina Commiphora." Molecules 23, no. 12: 3239.
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