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Open AccessArticle

Novel Terpenoids with Potent Cytotoxic Activities from Resina Commiphora

1
School of Chemical Science and Technology, Yunnan University, Kunming 650091, China
2
Guangdong Key Laboratory for Genome Stability & Disease Prevention, School of Pharmaceutical Sciences, Shenzhen University Health Science Center, Shenzhen 518060, China
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Molecules 2018, 23(12), 3239; https://doi.org/10.3390/molecules23123239
Received: 23 November 2018 / Revised: 4 December 2018 / Accepted: 6 December 2018 / Published: 7 December 2018
A novel sesquiterpene dimer, spirocommiphorfuran A (1); two new cadinane sesquiterpenoids, commiphorenes A (2) and B (3); along with three known terpenoids (46), were isolated from Resina Commiphora. The structures of these new compounds were characterized by NMR, HRESIMS, quantum chemical computation, and X-ray diffraction analysis. Compound 1 features a 7-oxabicyclo[2.2.1]heptane-2-ene core, representing the first example of germacrane-type sesquiterpene dimer fused via a spiro ring system. Compound 2 is a novel sesquiterpene with a completely new carbon skeleton, which is characteristic of an additional carbon attaching to the cadinane backbone via a carbon–carbon bond. Additionally, compounds 2 and 4 exert acceptable cytotoxicity toward normal cells and high selectivity in cancer cells, especially in HepG2 cells. View Full-Text
Keywords: Resina Commiphora; terpenoids; X-ray; quantum chemical computation; cytotoxic activities Resina Commiphora; terpenoids; X-ray; quantum chemical computation; cytotoxic activities
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MDPI and ACS Style

Hu, B.-Y.; Qin, D.-P.; Wang, S.-X.; Qi, J.-J.; Cheng, Y.-X. Novel Terpenoids with Potent Cytotoxic Activities from Resina Commiphora. Molecules 2018, 23, 3239.

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