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Molecules 2018, 23(12), 3218; https://doi.org/10.3390/molecules23123218

Mollicellins O–R, Four New Depsidones Isolated from the Endophytic Fungus Chaetomium sp. Eef-10

1
Guangdong Key Laboratory for Innovative Development and Utilization of Forest Plant Germplasm, College of Forestry and Landscape Architecture, South China Agricultural University, Guangzhou 510642, China
2
Guangdong Province Key Laboratory of Microbial Signals and Disease Control, South China Agricultural University, Guangzhou 510642, China
3
College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China
4
Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peaking Union Medical College, Beijing 100050, China
5
National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, South China Agricultural University, Guangzhou 510642, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 15 November 2018 / Revised: 2 December 2018 / Accepted: 4 December 2018 / Published: 5 December 2018
PDF [435 KB, uploaded 5 December 2018]

Abstract

Four new depsidones, mollicellins O–R (compounds 14), along with three known compounds 57, were isolated from cultures of the fungus Chaetomium sp. Eef-10, an endophyte isolated from Eucalyptus exserta. The structures of the new compounds were elucidated by analysis of the 1D and 2D NMR and HR-ESI-MS spectra. The known compounds were identified by comparison of their spectral data with published values. Compounds 17 were evaluated for antibacterial activities against Staphylococcus aureus (sensitive and resistant strains), Escherichia coli, Agrobacterium tumefaciens, Salmonella typhimurium, Pseudomonas lachrymans, Ralstonia solanacearum, Xanthomonas vesicatoria and cytotoxic activities against two human cancer cell lines (HepG2 and Hela). Mollicellin H (6) displayed best antibacterial activity, with IC50 values of 5.14 µg/mL against S. aureus ATCC29213 and 6.21 µg/mL against S. aureus N50, MRSA, respectively. Mollicellin O (1) and mollicellin I (7) also exhibited antibacterial activities against S. aureus ATCC29213 and S. aureus N50. Mollicellin G (5) was active against both two human cancer cell lines, with IC50 values of 19.64 and 13.97 µg/mL while compounds 6 and 7 only showed cytotoxic activity against one cell line. In addition, mollicellin O (1) showed antioxidant activity based on DPPH radical scavenging, with an IC50 value of 71.92 µg/mL.
Keywords: endophytic fungus; secondary metabolites; Chaetomium sp. Eef-10; antibacterial activity; cytotoxic activity; antioxidant activity endophytic fungus; secondary metabolites; Chaetomium sp. Eef-10; antibacterial activity; cytotoxic activity; antioxidant activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Ouyang, J.; Mao, Z.; Guo, H.; Xie, Y.; Cui, Z.; Sun, J.; Wu, H.; Wen, X.; Wang, J.; Shan, T. Mollicellins O–R, Four New Depsidones Isolated from the Endophytic Fungus Chaetomium sp. Eef-10. Molecules 2018, 23, 3218.

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