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Metabolomic Study to Determine the Mechanism Underlying the Effects of Sagittaria sagittifolia Polysaccharide on Isoniazid- and Rifampicin-Induced Hepatotoxicity in Mice

1
School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100102, China
2
Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China
3
Chongqing Academy of Chinese Materia Medica, Chongqing 400065, China
4
Beijing Institute of Biomedicine, Beijing 100091, China
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Molecules 2018, 23(12), 3087; https://doi.org/10.3390/molecules23123087
Received: 16 October 2018 / Revised: 19 November 2018 / Accepted: 19 November 2018 / Published: 27 November 2018
In this study, a non-targeted metabolic profiling method based on ultra-performance liquid chromatography-high resolution mass spectrometry (UPLC-HRMS) was used to characterize the plasma metabolic profile associated with the protective effects of the Sagittaria sagittifolia polysaccharide (SSP) on isoniazid (INH)—and rifampicin (RFP)-induced hepatotoxicity in mice. Fourteen potential biomarkers were identified from the plasma of SSP-treated mice. The protective effects of SSP on hepatotoxicity caused by the combination of INH and RFP (INH/RFP) were further elucidated by investigating the related metabolic pathways. INH/RFP was found to disrupt fatty acid metabolism, the tricarboxylic acid cycle, amino acid metabolism, taurine metabolism, and the ornithine cycle. The results of the metabolomics study showed that SSP provided protective effects against INH/RFP-induced liver injury by partially regulating perturbed metabolic pathways. View Full-Text
Keywords: ultra-performance liquid chromatography-high resolution mass spectrometry (UPLC-HRMS); isoniazid; rifampicin; Sagittaria sagittifolia polysaccharide; liver injury ultra-performance liquid chromatography-high resolution mass spectrometry (UPLC-HRMS); isoniazid; rifampicin; Sagittaria sagittifolia polysaccharide; liver injury
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Ke, X.-H.; Wang, C.-G.; Luo, W.-Z.; Wang, J.; Li, B.; Lv, J.-P.; Dong, R.-J.; Ge, D.-Y.; Han, Y.; Yang, Y.-J.; Tu-Erxun, R.-Y.; Liu, H.-S.; Wang, Y.-C.; Liao, Y. Metabolomic Study to Determine the Mechanism Underlying the Effects of Sagittaria sagittifolia Polysaccharide on Isoniazid- and Rifampicin-Induced Hepatotoxicity in Mice. Molecules 2018, 23, 3087.

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