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Molecules 2018, 23(1), 87;

Lupane Triterpenes from the Leaves of Acanthopanax gracilistylus

School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, Hunan, China
College of Pharmacy, Wonkwang University, Iksan 570-749, Korea
Broad-Ocean Bio-Science and Technique Co., Ltd. of Changsha, Changsha 410205, Hunan, China
Department of Oriental Medical Food & Nutrition, Semyung University, Jecheon 27136, Korea
School of Pharmacy, KyungHee University, Seoul 130-701, Korea
These authors contribute equally to this work.
Authors to whom correspondence should be addressed.
Received: 1 December 2017 / Revised: 27 December 2017 / Accepted: 29 December 2017 / Published: 1 January 2018
(This article belongs to the Section Natural Products Chemistry)
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The phytochemical study on the leaves of Acanthopanax gracilistylus (Araliaceae) resulted in the discovery of a new lupane-triterpene compound, acangraciligenin S (1), and a new lupane-triterpene glycoside, acangraciliside S (2), as well as two known ones, 3α,11α-dihydroxy-lup-20(29)-en-23,28-dioic acid (3) and acankoreoside C (4). Their chemical structures were elucidated by mass, 1D- and 2D-nuclear magnetic resonance (NMR) spectroscopy. The chemical structures of the new compounds 1 and 2 were determined to be 1β,3α-dihydroxy-lup-20(29)-en-23, 28-dioic acid and 1β,3α-dihydroxy-lup-20(29)-en-23,28-dioic acid 28-O-[α-l-rhamnopyranosyl-(1→4)-β-d-glucopyranosyl-(1→6)-β-d-glucopyranosyl] ester, respectively. The anti-neuroinflammatory activity of the selective compounds, 1 and 3, were evaluated with lipopolysaccharide (LPS)-induced BV2 microglia. The tested compounds showed moderate inhibitory effect of nitric oxide (NO) production. View Full-Text
Keywords: Acanthopanax gracilistylus; Araliaceae; lupane-triterpene; acangraciligenin S; acangraciliside S Acanthopanax gracilistylus; Araliaceae; lupane-triterpene; acangraciligenin S; acangraciliside S

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Li, X.-J.; Zou, Q.-P.; Wang, X.; Kim, K.-W.; Lu, M.-F.; Ko, S.-K.; Yook, C.-S.; Kim, Y.-C.; Liu, X.-Q. Lupane Triterpenes from the Leaves of Acanthopanax gracilistylus. Molecules 2018, 23, 87.

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