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Open AccessArticle

Two Novel Proline-Containing Catechin Glucoside from Water-Soluble Extract of Codonopsis pilosula

1
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China
2
School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450008, China
3
University of Chinese Academy of Sciences, Beijing 100049, China
4
Guangdong Key Laboratory for Genome Stability & Disease Prevention, School of Pharmaceutical Sciences, School of Medicine, Shenzhen University Health Science Center, Shenzhen 518060, China
*
Author to whom correspondence should be addressed.
Molecules 2018, 23(1), 180; https://doi.org/10.3390/molecules23010180
Received: 16 December 2017 / Revised: 2 January 2018 / Accepted: 8 January 2018 / Published: 16 January 2018
(This article belongs to the Section Natural Products Chemistry)
Choushenflavonoids A (1) and B (2), two unusual proline-containing catechin glucosides, were isolated from the roots of Codonopsis pilosula cultivated in a high-altitude location of Yunnan province. Their structures were determined by spectroscopic data and chemical methods. Specifically, the absolute configuration of glucose residue in 1 and 2 was assigned by acid hydrolysis followed by derivatization and gas chromatography (GC) analysis. In addition, biological evaluation of 1 and 2 against Sirtuin 1 (SIRT1) was carried out. View Full-Text
Keywords: Codonopsis pilosula; Catechin glucosides; Choushenflavonoids A and B; Proline; SIRT1 Codonopsis pilosula; Catechin glucosides; Choushenflavonoids A and B; Proline; SIRT1
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MDPI and ACS Style

Qin, F.-Y.; Cheng, L.-Z.; Yan, Y.-M.; Liu, B.-H.; Cheng, Y.-X. Two Novel Proline-Containing Catechin Glucoside from Water-Soluble Extract of Codonopsis pilosula. Molecules 2018, 23, 180.

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