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Molecules 2018, 23(1), 180; https://doi.org/10.3390/molecules23010180

Two Novel Proline-Containing Catechin Glucoside from Water-Soluble Extract of Codonopsis pilosula

1
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China
2
School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450008, China
3
University of Chinese Academy of Sciences, Beijing 100049, China
4
Guangdong Key Laboratory for Genome Stability & Disease Prevention, School of Pharmaceutical Sciences, School of Medicine, Shenzhen University Health Science Center, Shenzhen 518060, China
*
Author to whom correspondence should be addressed.
Received: 16 December 2017 / Revised: 2 January 2018 / Accepted: 8 January 2018 / Published: 16 January 2018
(This article belongs to the Section Natural Products Chemistry)
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Abstract

Choushenflavonoids A (1) and B (2), two unusual proline-containing catechin glucosides, were isolated from the roots of Codonopsis pilosula cultivated in a high-altitude location of Yunnan province. Their structures were determined by spectroscopic data and chemical methods. Specifically, the absolute configuration of glucose residue in 1 and 2 was assigned by acid hydrolysis followed by derivatization and gas chromatography (GC) analysis. In addition, biological evaluation of 1 and 2 against Sirtuin 1 (SIRT1) was carried out. View Full-Text
Keywords: Codonopsis pilosula; Catechin glucosides; Choushenflavonoids A and B; Proline; SIRT1 Codonopsis pilosula; Catechin glucosides; Choushenflavonoids A and B; Proline; SIRT1
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Qin, F.-Y.; Cheng, L.-Z.; Yan, Y.-M.; Liu, B.-H.; Cheng, Y.-X. Two Novel Proline-Containing Catechin Glucoside from Water-Soluble Extract of Codonopsis pilosula. Molecules 2018, 23, 180.

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