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Molecules 2017, 22(9), 1536;

Skin Penetration Enhancement by Natural Oils for Dihydroquercetin Delivery

Department of Clinical Pharmacy, Lithuanian University of Health Sciences, Sukilėlių pr. 13, Kaunas 50166, Lithuania
Institut de Chimie des Substances Naturelles, CNRS UPR 2301, University Paris-Sud, Université Paris-Saclay, Avenue de la Terrasse, Gif-sur-Yvette 91198, France
Author to whom correspondence should be addressed.
Received: 23 August 2017 / Accepted: 10 September 2017 / Published: 12 September 2017
(This article belongs to the Section Natural Products Chemistry)
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Natural oils are commonly used in topical pharmaceutical formulations as emulsifiers, stabilizers or solubility enhancers. They are presented as safe and inert components, mainly used for formulation purposes. It is confirmed that natural oils can affect the skin penetration of various substances. Fatty acids are mainly responsible for this effect. Current understanding lacks reliable scientific data on penetration of natural oils into the skin and their skin penetration enhancement potential. In the current study, fatty acid content analysis was used to determine the principal fatty acids in soybean, olive, avocado, sea-buckthorn pulp, raspberry seed and coconut oils. Time of flight secondary ion mass spectrometry bioimaging was used to determine the distribution of these fatty acids in human skin ex vivo after application of the oils. Skin penetration enhancement ratios were determined for a perspective antioxidant compound dihydroquercetin. The results demonstrated skin penetration of fatty acids from all oils tested. Only soybean and olive oils significantly increased the skin distribution of dihydroquercetin and can be used as skin penetration enhancers. However, no correlation can be determined between the fatty acids’ composition and skin penetration enhancement using currently available methodological approaches. This indicates that potential chemical penetration enhancement should be evaluated during formulation of topically applied products containing natural oils. View Full-Text
Keywords: natural oils; skin penetration enhancement; dihydroquercetin; natural oils skin penetration; fatty acids penetration natural oils; skin penetration enhancement; dihydroquercetin; natural oils skin penetration; fatty acids penetration

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Čižinauskas, V.; Elie, N.; Brunelle, A.; Briedis, V. Skin Penetration Enhancement by Natural Oils for Dihydroquercetin Delivery. Molecules 2017, 22, 1536.

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