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Molecules 2017, 22(7), 1073;

Nortriterpenoids from the Fruiting Bodies of the Mushroom Ganoderma resinaceum

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau 999078, China
Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Jiangsu Key Laboratory for High Technology Research of TCM Formulae, and National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China
Authors to whom correspondence should be addressed.
Received: 2 June 2017 / Revised: 21 June 2017 / Accepted: 22 June 2017 / Published: 28 June 2017
(This article belongs to the Section Natural Products Chemistry)
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Ganoderma resinaceum is usually used as ethnomedicine for immune-regulation, hyperglycemia, and liver disease. To date, only a few chemical constituents have been reported from G. resinaceum. In this study, fifteen nortriterpenoids including six new nortriterpenoids (16) and nine known analogs (715), were separated and purified from the fruiting bodies of G. resinaceum. New compounds were identified as lucidone I (1), lucidone J (2), lucidone K (3), lucidone I (4), ganosineniol B (5), and ganosineniol C (6), based on analysis of extensive spectroscopic data (high resolution mass spectrometry (HRMS), nuclear magnetic resonance (NMR), infrared (IR), and ultraviolet (UV)). The known compounds were assigned as lucidone A (7), lucidone B (8), lucidone H (9), lucidone E (10), lucidone F (11), lucidone D (12), lucidone C (13), ganoderense F (14), and ganosineniol A (15), by comparing their spectroscopic data with those reported in the literature. Compounds 3, 4, and 713 were examined for α-glucosidase inhibitory activity and display no significant activity, but the finding may support that the side chain of ganoderma triterpenoids played an important role in α-glucosidase inhibitory activity. View Full-Text
Keywords: Ganoderma resinaceum; nortriterpenoid; lucidones I–L; α-glucosidase Ganoderma resinaceum; nortriterpenoid; lucidones I–L; α-glucosidase

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Chen, X.-Q.; Chen, L.-X.; Zhao, J.; Tang, Y.-P.; Li, S.-P. Nortriterpenoids from the Fruiting Bodies of the Mushroom Ganoderma resinaceum. Molecules 2017, 22, 1073.

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