Mesoporous Silica Nanoparticles as Carriers for Intracellular Delivery of Nucleic Acids and Subsequent Therapeutic Applications
Abstract
:1. Introduction
2. General Strategies for Preparation of Nucleic Acid-MSN Complexes
3. MSNs as Carriers for Intracellular Delivery of Nucleic Acids and Nucleic Acids-Guided Therapeutic Applications
3.1. DNA-MSN Complexes for DNA Delivery and DNA-Guided Therapeutics
3.2. MiRNA/siRNA-MSN Complexes for miRNA/siRNA Delivery and miRNA/siRNA-Guided Therapeutics
3.3. ASO-MSN Complexes for ASO Delivery and ASO-Guided Therapeutics
4. Perspective
Author Contributions
Conflicts of Interest
References
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MSNs | Nucleic Acids/Fluorophore-Labeled Nucleic Acids | Ref. | ||||
---|---|---|---|---|---|---|
MSN Size (nm) | Pore Size (nm) | Surface Coatings | Name | Antisense Strand (5’-3’) | Sense Strand (5’-3’) | |
~200 | ~2.71 | Carbosilane dendrons | ssDNACy3 | Cy3-TTATCGCTGATTCAAGACTGA | / | [52] |
~180 | / | l-histidine | pDNA-Luciferase | / | / | [53] |
~120 | ~2.5 | PEI | pDNA-GFP | / | / | [37] |
~70 | ~3.5–5 | Amine with disulfide linker | dsDNA | CTGTGGTTGTGTTTGCACTTT | AGTGCAAACACAACCACAGTT | [54] |
~80 | ~2.6 | Poly-arginine | pDNA-mCherry | / | / | [40] |
~250 | ~23 | Amine | pDNA-GFP | / | / | [55] |
~130 | ~12 | Amine | dsDNA | TCAGAGAGTTAGAGAGTTAGAGAGTCAGAGAGTTAGAGAGTTAGAGAGTCAGAGAGTTAGAGAGTTAGAGAG | CTCTCTAACTCTCTAACTCTCTGACTCTC-TAACTCTCTAACTCTCTGACTCTCTAACTCTCTAACTCTCTGA | [56] |
~150 | / | Amine | pDNA-HNF3β | / | / | [46] |
~205 | ~2.64 | Amine | pDNA-BMP2 | / | / | [57] |
~200 | ~3 | Amine | pDNA-PDGF | / | / | [58] |
~74 | / | Poly-amidoamine | miR-34a | UGGCAGUGUCUUAGCUGGUUGU | CAAUCAGCAAGUAUACUGCCCU | [59] |
~219.5 | ~18.8 | Bifunctional peptide | miR-29b | GCUGGUUUCAUAUGGUGGUUUAGA | GCUGGUUUCAUAUGGUGGUUUAGA | [60] |
~250 | ~3.5 | Calcium | miR-5106 | AGGUCUGUAGCUCAGUUGGCAGA-FAM | UCUGCCAACUGAGCUACAGACCU | [61] |
~150 | ~10 | PDMAEMA | siRNA-PLK | UUAAGCAGCUCGUUAAUGGTT-FAM or Cy3 | CCAUUAACGAGCUGCUUAATT | [62] |
~130 | ~2.5 | PEI | siRNA-Kras | UUUCCUACUAGGACCAUAGGT | CUAUGGUCCUAGUAGGAAATT | [63] |
~100–200 | ~28 | Polylysine | siRNA-MirK | UUCCGGAACAUGAAGUGCCGC | GGCACUUCAUGUUCCGGAAUU | [39] |
~100–200 | ~28 | Polylysine | siRNA-S10 | ACGUCGCAGUAACUGUUGCUU | ACGUCGCAGUAACUGUUGCUU | [39] |
~100–200 | ~11 | PDMAEA | siRNA-PLK | UUAAGCAGCUCGUUAAUGGTT | CCAUUAACGAGCUGCUUAATT | [64] |
~100 | / | PEI | siRNA-HER2 | UUGGGCAUGGACUCAAACGUGUU | CACGUUUGAGUCCAUGCCCAAUU | [65] |
~50 | ~3.6 | PEI | siRNA-VEGF | GAUCUCAUCAGGGUACUCCTT | GGAGUACCCUGAUGAGAUCTT | [66,67,68] |
~51 | / | PEI | siRNA-Pgp | CGGAAGGCCUAAUGCCGAATT | UUGCGCAUUAGGCCUUCCGTT | [69] |
~110 | / | Amine with disulfide linker | PNA-Bcl2 | TCTCCCAGCGTGCGCCAT-Cy5 | / | [70] |
~60 | / | Amine | Double-stranded ASOs targeting miR-21 | GTCAACATCAGTCTGATAAGCTATGTCGC-FAM | DABCYL-GCGACATAGCT | [71] |
~120 | ~3 | Amine | Antagomir-122 | ACAAACACCATTGTCACACTCCA | / | [72] |
~105 | ~3.2 | Amines | Antagomir-21 | UCAACAUCAGUCUGAUAAGCUA | / | [73] |
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Cha, W.; Fan, R.; Miao, Y.; Zhou, Y.; Qin, C.; Shan, X.; Wan, X.; Li, J. Mesoporous Silica Nanoparticles as Carriers for Intracellular Delivery of Nucleic Acids and Subsequent Therapeutic Applications. Molecules 2017, 22, 782. https://doi.org/10.3390/molecules22050782
Cha W, Fan R, Miao Y, Zhou Y, Qin C, Shan X, Wan X, Li J. Mesoporous Silica Nanoparticles as Carriers for Intracellular Delivery of Nucleic Acids and Subsequent Therapeutic Applications. Molecules. 2017; 22(5):782. https://doi.org/10.3390/molecules22050782
Chicago/Turabian StyleCha, Wenzhang, Rengen Fan, Yufeng Miao, Yong Zhou, Chenglin Qin, Xiangxiang Shan, Xinqiang Wan, and Jinbo Li. 2017. "Mesoporous Silica Nanoparticles as Carriers for Intracellular Delivery of Nucleic Acids and Subsequent Therapeutic Applications" Molecules 22, no. 5: 782. https://doi.org/10.3390/molecules22050782