Next Article in Journal
Synthesis and Cytotoxicity of N-Substituted Dibenzo[a,j]xanthene-3,11-dicarboxamide Derivatives
Next Article in Special Issue
Strengthening Triterpene Saponins Biosynthesis by Over-Expression of Farnesyl Pyrophosphate Synthase Gene and RNA Interference of Cycloartenol Synthase Gene in Panax notoginseng Cells
Previous Article in Journal
Isolation, Characterization and Antiproliferative Activity of New Metabolites from the South African Endemic Red Algal Species Laurencia alfredensis
Previous Article in Special Issue
Combination of Morroniside and Diosgenin Prevents High Glucose-Induced Cardiomyocytes Apoptosis
Open AccessReview

Solanesol Biosynthesis in Plants

Tobacco Research Institute of Chinese Academy of Agricultural Sciences, Qingdao 266101, China
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Molecules 2017, 22(4), 510;
Received: 1 March 2017 / Revised: 18 March 2017 / Accepted: 22 March 2017 / Published: 23 March 2017
(This article belongs to the Special Issue Isoprenoid Biosynthesis)
Solanesol is a non-cyclic terpene alcohol composed of nine isoprene units that mainly accumulates in solanaceous plants. Solanesol plays an important role in the interactions between plants and environmental factors such as pathogen infections and moderate-to-high temperatures. Additionally, it is a key intermediate for the pharmaceutical synthesis of ubiquinone-based drugs such as coenzyme Q10 and vitamin K2, and anti-cancer agent synergizers such as N-solanesyl-N,N′-bis(3,4-dimethoxybenzyl) ethylenediamine (SDB). In plants, solanesol is formed by the 2-C-methyl-d-erythritol 4-phosphate (MEP) pathway within plastids. Solanesol’s biosynthetic pathway involves the generation of C5 precursors, followed by the generation of direct precursors, and then the biosynthesis and modification of terpenoids; the first two stages of this pathway are well understood. Based on the current understanding of solanesol biosynthesis, we here review the key enzymes involved, including 1-deoxy-d-xylulose 5-phosphate synthase (DXS), 1-deoxy-d-xylulose 5-phosphate reductoisomerase (DXR), isopentenyl diphosphate isomerase (IPI), geranyl geranyl diphosphate synthase (GGPPS), and solanesyl diphosphate synthase (SPS), as well as their biological functions. Notably, studies on microbial heterologous expression and overexpression of key enzymatic genes in tobacco solanesol biosynthesis are of significant importance for medical uses of tobacco. View Full-Text
Keywords: solanesol; function; biosynthetic pathway; key enzymes solanesol; function; biosynthetic pathway; key enzymes
Show Figures

Figure 1

MDPI and ACS Style

Yan, N.; Liu, Y.; Zhang, H.; Du, Y.; Liu, X.; Zhang, Z. Solanesol Biosynthesis in Plants. Molecules 2017, 22, 510.

AMA Style

Yan N, Liu Y, Zhang H, Du Y, Liu X, Zhang Z. Solanesol Biosynthesis in Plants. Molecules. 2017; 22(4):510.

Chicago/Turabian Style

Yan, Ning; Liu, Yanhua; Zhang, Hongbo; Du, Yongmei; Liu, Xinmin; Zhang, Zhongfeng. 2017. "Solanesol Biosynthesis in Plants" Molecules 22, no. 4: 510.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop