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Molecules 2017, 22(3), 504;

The Anti-Allergic Rhinitis Effect of Traditional Chinese Medicine of Shenqi by Regulating Mast Cell Degranulation and Th1/Th2 Cytokine Balance

State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China
Department of Liver disease, Army General Hospital of PLA, Beijing 100700, China
Department of Pharmacy, Changji Vocational and Technical College, Changji 831100, China
Xinjiang Jinshikang Pharmaceutical Co., Ltd., Urumchi 830000, China
Author to whom correspondence should be addressed.
Academic Editor: Maurizio Battino
Received: 21 February 2017 / Revised: 21 March 2017 / Accepted: 21 March 2017 / Published: 22 March 2017
(This article belongs to the Section Natural Products Chemistry)
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Shenqi is a traditional Chinese polyherbal medicine has been widely used for the treatment of allergic rhinitis (AR). The aim of this study was to investigate the anti-allergic rhinitis activity of Shenqi and explore its underlying molecular mechanism. Ovalbumin (OVA)-induced allergic rhinitis rat model was used to evaluate the anti-allergic rhinitis effect of Shenqi. The effect of Shenqi on IgE-mediated degranulation was measured using rat basophilic leukemia (RBL-2H3) cells. Primary spleen lymphocytes were isolated to investigate the anti-allergic mechanism of Shenqi by detecting the expression of transcription factors via Western blot and the level of cytokines (IL-4 and IFN-γ) via ELISA. In OVA-induced AR rat models, Shenqi relieved the allergic rhinitis symptoms, inhibited the histopathological changes of nasal mucosa, and reduced the levels of IL-4 and IgE. The results from the in vitro study certified that Shenqi inhibited mast cell degranulation. Furthermore, the results of GATA3, T-bet, p-STAT6, and SOCS1 expression and production of IFN-γ and IL-4 demonstrated that Shenqi balanced the ratio of Th1/Th2 (IFN-γ/IL-4) in OVA-stimulated spleen lymphocytes. In conclusion, these results suggest that Shenqi exhibits an obvious anti-allergic effect by suppressing the mast cell-mediated allergic response and by improving the imbalance of Th1/Th2 ratio in allergic rhinitis. View Full-Text
Keywords: allergic rhinitis; anti-allergic activity; Shenqi; degranulation; Th1/Th2 balance allergic rhinitis; anti-allergic activity; Shenqi; degranulation; Th1/Th2 balance

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Shao, Y.-Y.; Zhou, Y.-M.; Hu, M.; Li, J.-Z.; Chen, C.-J.; Wang, Y.-J.; Shi, X.-Y.; Wang, W.-J.; Zhang, T.-T. The Anti-Allergic Rhinitis Effect of Traditional Chinese Medicine of Shenqi by Regulating Mast Cell Degranulation and Th1/Th2 Cytokine Balance. Molecules 2017, 22, 504.

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