New Chiral Ebselen Analogues with Antioxidant and Cytotoxic Potential
AbstractNew chiral camphane-derived benzisoselenazol-3(2H)-ones and corresponding diselenides have been synthetized using a convenient one-pot procedure. Se-N bond was efficiently converted to an Se-Se bond, which could also be easily re-oxidized to the initial benzisoselenazolone moiety. The antioxidant activity of camphor derivatives was evaluated and compared to the reactivity of a series of N-amino acid benzisoselenazol-3(2H)-ones obtained by a modified procedure involving the improved synthesis and isolation of the diseleno bis(dibenzoic) acid. The most efficient peroxide scavengers, N-bornyl and N-leucine methyl ester benzisoselenazol-3(2H)-ones, were further evaluated as cytotoxic agents on four cancer cell lines (MCF-7, HEP G2, HL 6, and DU 145) and normal cell line PNT1A. The highest antiproliferative potential was evaluated for two compounds bearing a 3-methylbutyl carbon chain, N-leucine methyl ester and N-3-methylbutyl benzisoselenazol-3(2H)-ones. View Full-Text
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Pacuła, A.J.; Kaczor, K.B.; Antosiewicz, J.; Janecka, A.; Długosz, A.; Janecki, T.; Wojtczak, A.; Ścianowski, J. New Chiral Ebselen Analogues with Antioxidant and Cytotoxic Potential. Molecules 2017, 22, 492.
Pacuła AJ, Kaczor KB, Antosiewicz J, Janecka A, Długosz A, Janecki T, Wojtczak A, Ścianowski J. New Chiral Ebselen Analogues with Antioxidant and Cytotoxic Potential. Molecules. 2017; 22(3):492.Chicago/Turabian Style
Pacuła, Agata J.; Kaczor, Katarzyna B.; Antosiewicz, Jędrzej; Janecka, Anna; Długosz, Angelika; Janecki, Tomasz; Wojtczak, Andrzej; Ścianowski, Jacek. 2017. "New Chiral Ebselen Analogues with Antioxidant and Cytotoxic Potential." Molecules 22, no. 3: 492.
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