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Secondary Metabolites from the Marine-Derived Fungus Dichotomomyces sp. L-8 and Their Cytotoxic Activity

School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China
Guangdong Technology Research Center for Advanced Chinese Medicine, Guangzhou 510006, China
Zhongshan School of Medicine, Sun Yat-sen University, 74 Zhongshan Road II, Guangzhou 510080, China
School of Chemistry, Sun Yat-sen University, Guangzhou 510275, China
State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Avenida Wai Long, Taipa 519020, Macau (SAR), China
Department of Biochemistry, Faculty of Medicine, Srinakharinwirot University, Bangkok 10110, Thailand
Institute of Chemical Sciences, Gomal University, D.I.Khan 29050, Pakistan
Author to whom correspondence should be addressed.
Academic Editor: Maria G. Miguel
Molecules 2017, 22(3), 444;
Received: 8 February 2017 / Revised: 3 March 2017 / Accepted: 7 March 2017 / Published: 11 March 2017
PDF [525 KB, uploaded 11 March 2017]


Bioassay-guided isolation of the secondary metabolites from the fungus Dichotomomyces sp. L-8 associated with the soft coral Lobophytum crassum led to the discovery of two new compounds, dichotones A and B (1 and 2), together with four known compounds including dichotocejpin C (3), bis-N-norgliovictin (4), bassiatin (5) and (3R,6R)-bassiatin (6). The structures of these compounds were determined by 1D, 2D NMR and mass spectrometry. (3R,6R)-bassiatin (6) displayed significant cytotoxic activities against the human breast cancer cell line MDA-MB-435 and the human lung cancer cell line Calu3 with IC50 values of 7.34 ± 0.20 and 14.54 ± 0.01 μM, respectively, while bassiatin (5), the diastereomer of compound 6, was not cytotoxic. View Full-Text
Keywords: Dichotomomyces sp.; secondary metabolites; structure elucidation; cytotoxic activity Dichotomomyces sp.; secondary metabolites; structure elucidation; cytotoxic activity

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Huang, L.-H.; Chen, Y.-X.; Yu, J.-C.; Yuan, J.; Li, H.-J.; Ma, W.-Z.; Watanapokasin, R.; Hu, K.-C.; Niaz, S.I.; Yang, D.-P.; Lan, W.-J. Secondary Metabolites from the Marine-Derived Fungus Dichotomomyces sp. L-8 and Their Cytotoxic Activity. Molecules 2017, 22, 444.

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