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Molecules 2017, 22(3), 419;

Spotlight on Biomimetic Systems Based on Lyotropic Liquid Crystal

Laboratory of Biomaterials and Nanotechnology, University of Sorocaba (UNISO), Sorocaba, SP 18078-005, Brazil
Laboratory of Post-Graduate Program in Biotechnology and Environmental Monitoring (PPGBMA), University of São Carlos (UFSCAR), Sorocaba, SP 18052-780, Brazil
Laboratory of Biomaterials (LABIOMAT), Pontificial University Catholic (PUC), Sorocaba, SP 18030-070, Brazil
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 23 January 2017 / Accepted: 28 February 2017 / Published: 7 March 2017
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The behavior of lyotropic biomimetic systems in drug delivery was reviewed. These behaviors are influenced by drug properties, the initial water content, type of lyotropic liquid crystals (LLC), swell ability, drug loading rate, the presence of ions with higher or less kosmotropic or chaotropic force, and the electrostatic interaction between the drug and the lipid bilayers. The in vivo interaction between LCC—drugs, and the impact on the bioavailability of drugs, was reviewed. The LLC with a different architecture can be formed by the self-assembly of lipids in aqueous medium, and can be tuned by the structures and physical properties of the emulsion. These LLC lamellar phase, cubic phase, and hexagonal phase, possess fascinating viscoelastic properties, which make them useful as a dispersion technology, and a highly ordered, thermodynamically stable internal nanostructure, thereby offering the potential as a sustained drug release matrix for drug delivery. In addition, the biodegradable and biocompatible nature of lipids demonstrates a minimum toxicity and thus, they are used for various routes of administration. This review is not intended to provide a comprehensive overview, but focuses on the advantages over non modified conventional materials and LLC biomimetic properties. View Full-Text
Keywords: liquid crystals; lyotropic liquid crystals; biomimetic systems; immunodetection; drug carriers liquid crystals; lyotropic liquid crystals; biomimetic systems; immunodetection; drug carriers

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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de Souza, J.F.; Pontes, K.S.; Alves, T.F.R.; Amaral, V.A.; Rebelo, M.A.; Hausen, M.A.; Chaud, M.V. Spotlight on Biomimetic Systems Based on Lyotropic Liquid Crystal. Molecules 2017, 22, 419.

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