The Structure-Activity Relationship of Pterostilbene Against Candida albicans Biofilms
AbstractCandida albicans biofilms contribute to invasive infections and dramatic drug resistance, and anti-biofilm agents are urgently needed in the clinic. Pterostilbene (PTE) is a natural plant product with potentials to be developed as an anti-biofilm agent. In this study, we evaluated the structure-activity relationship (SAR) of PTE analogues against C. albicans biofilms. XTT (Sodium 2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide inner salt) reduction assay was used to evaluate the activity of the analogues against C. albicans biofilms. Knowing that hyphal formation is essential for C. albicans biofilms, anti-hyphal assay was further carried out. By comparing a series of compounds tested in this study, we found that compounds with para-hydroxy (–OH) in partition A exhibited better activity than those with other substituents in the para position, and the double bond in partition B and meta-dimethoxy (–OCH3) in partition C both contributed to the best activity. Consistent results were obtained by anti-hyphal assay. Collectively, para-hydroxy (–OH), double bond and meta-dimethoxy (–OCH3) are all needed for the best activity of PTE against C. albicans biofilms. View Full-Text
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Hu, D.-D.; Zhang, R.-L.; Zou, Y.; Zhong, H.; Zhang, E.-S.; Luo, X.; Wang, Y.; Jiang, Y.-Y. The Structure-Activity Relationship of Pterostilbene Against Candida albicans Biofilms. Molecules 2017, 22, 360.
Hu D-D, Zhang R-L, Zou Y, Zhong H, Zhang E-S, Luo X, Wang Y, Jiang Y-Y. The Structure-Activity Relationship of Pterostilbene Against Candida albicans Biofilms. Molecules. 2017; 22(3):360.Chicago/Turabian Style
Hu, Dan-Dan; Zhang, Ri-Li; Zou, Yong; Zhong, Hua; Zhang, En-Sheng; Luo, Xiang; Wang, Yan; Jiang, Yuan-Ying. 2017. "The Structure-Activity Relationship of Pterostilbene Against Candida albicans Biofilms." Molecules 22, no. 3: 360.
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