The Structure-Activity Relationship of Pterostilbene Against Candida albicans Biofilms
Abstract
:1. Introduction
2. Results
2.1. In the Para Position of Partition A, Hydroxy (–OH) Takes Advantages over Other Substituents
2.2. In Partition B, the Double Bond Contributes to the Best Activity
2.3. In Partition C, Meta-Dimethoxy (–OCH3) Contributes to the Best Activity
3. Discussion and Conclusion
4. Materials and Methods
4.1. Strains, Culture, and Agents
4.2. In vitro Biofilm Formation Assay
4.3. Hyphal Formation Assay
Supplementary Materials
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Name | Structure | SMIC80 (μg/mL) | |
---|---|---|---|
Biofilm Formation | Mature Biofilm | ||
PTE | 16 | 128 | |
C4 | 32–64 | 512 | |
C1 | >64 | >512 | |
C2 | >64 | >512 | |
C3 | >64 | >512 | |
B1 | >64 | >512 | |
B2 | >64 | >512 | |
C5 | >64 | >512 | |
C6 | 32-64 | 512 | |
B3 | 32 | 128–256 | |
C7 | >64 | >512 | |
B4 | >64 | >512 | |
B6 | 64 | >512 | |
B5 | >64 | >512 | |
C8 | >64 | >512 | |
C9 | >64 | >512 |
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Hu, D.-D.; Zhang, R.-L.; Zou, Y.; Zhong, H.; Zhang, E.-S.; Luo, X.; Wang, Y.; Jiang, Y.-Y. The Structure-Activity Relationship of Pterostilbene Against Candida albicans Biofilms. Molecules 2017, 22, 360. https://doi.org/10.3390/molecules22030360
Hu D-D, Zhang R-L, Zou Y, Zhong H, Zhang E-S, Luo X, Wang Y, Jiang Y-Y. The Structure-Activity Relationship of Pterostilbene Against Candida albicans Biofilms. Molecules. 2017; 22(3):360. https://doi.org/10.3390/molecules22030360
Chicago/Turabian StyleHu, Dan-Dan, Ri-Li Zhang, Yong Zou, Hua Zhong, En-Sheng Zhang, Xiang Luo, Yan Wang, and Yuan-Ying Jiang. 2017. "The Structure-Activity Relationship of Pterostilbene Against Candida albicans Biofilms" Molecules 22, no. 3: 360. https://doi.org/10.3390/molecules22030360