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Molecules 2017, 22(12), 2214;

The Use of Poly-d,l-lactic Acid (PDLLA) Devices for Bone Augmentation Techniques: A Systematic Review

Multidisciplinary Department of Medical-Surgical and Dental Specialties, University of Campania “Luigi Vanvitelli”, Via Luigi De Crecchio, 6, 80138 Naples, Italy
Author to whom correspondence should be addressed.
Received: 8 November 2017 / Revised: 4 December 2017 / Accepted: 8 December 2017 / Published: 13 December 2017
(This article belongs to the Section Medicinal Chemistry)
Full-Text   |   PDF [380 KB, uploaded 13 December 2017]   |  


Poly-d,l-lactic acid (PDLLA) has been proposed in dentistry for regenerative procedures in the form of membranes, screws, and pins. The aim of this review was to evaluate the efficacy of bone augmentation techniques using PDLLA devices. A literature search was carried out by two independent and calibrated reviewers. All interventional and observational studies assessing the efficacy of bone augmentation techniques using PDLLA devices were included. Six studies were included. The relevant variability of design and methods impeded any qualitative or quantitative comparison. Ease of handling, absence of a re-entry phase, moldability of foils, and good soft-tissue response were appreciated characteristics of PDLLA devices. Some drawbacks such as the risk of membrane exposition, a prolonged adsorbability, and a tendency to a fibrous encapsulation of the PDLLA devices have been described, although the clinical significance of these findings is unclear. Clinical data about PDLLA devices for bone regeneration are very scarce and heterogenous. Well-designed randomized controlled trials comparing the use of PDLLA foils and pins with conventional membranes for bone regeneration are strongly encouraged in order to understand the real clinical benefits/drawbacks of this technique. View Full-Text
Keywords: poly-d,l-lactic acid; bone augmentation; systematic review poly-d,l-lactic acid; bone augmentation; systematic review

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Annunziata, M.; Nastri, L.; Cecoro, G.; Guida, L. The Use of Poly-d,l-lactic Acid (PDLLA) Devices for Bone Augmentation Techniques: A Systematic Review. Molecules 2017, 22, 2214.

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