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Molecules 2017, 22(12), 2065;

Outlook on the Application of Metal-Liganded Bioactives for Stimuli-Responsive Release

Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 7 York Road, Parktown 2193, South Africa
Author to whom correspondence should be addressed.
Received: 13 October 2017 / Revised: 13 November 2017 / Accepted: 25 November 2017 / Published: 26 November 2017
(This article belongs to the Special Issue Coordination Chemistry for Devices and Functional Materials)
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Direct metal-liganded bioactive coordination complexes are known to be sensitive to stimuli such as pH, light, ion activation, or redox cues. This results in the controlled release of the bioactive(s). Compared to other drug delivery strategies based on metal complexation, this type of coordination negates a multi-step drug loading methodology and offers customized physiochemical properties through judicious choice of modulating ancillary ligands. Bioactive release depends on simple dissociative kinetics. Nonetheless, there are challenges encountered when translating the pure coordination chemistry into the biological and physiological landscape. The stability of the metal–bioactive complex in the biological milieu may be compromised, disrupting the stimuli-responsive release mechanism, with premature release of the bioactive. Research has therefore progressed to the incorporation of metal-liganded bioactives with established drug delivery strategies to overcome these limitations. This review will highlight and critically assess current research interventions in order to predict the direction that pharmaceutical scientists could pursue to arrive at tailored and effective metal-liganded bioactive carriers for stimuli-responsive drug release. View Full-Text
Keywords: metal-liganded bioactive; drug carrier; stimuli-responsive release; bioinorganic medicine metal-liganded bioactive; drug carrier; stimuli-responsive release; bioinorganic medicine

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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M’bitsi-Ibouily, G.C.; Marimuthu, T.; Kumar, P.; du Toit, L.C.; Choonara, Y.E.; Kondiah, P.P.D.; Pillay, V. Outlook on the Application of Metal-Liganded Bioactives for Stimuli-Responsive Release. Molecules 2017, 22, 2065.

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