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Open AccessReview

Update on Phytochemistry and Pharmacology of Naturally Occurring Resveratrol Oligomers

by Jie Shen 1,2, Qiang Zhou 1,2,3, Pei Li 1,2, Zhiqiang Wang 1,2,4, Shuangshuang Liu 1,2, Chunnian He 1,2,*, Chunhong Zhang 5,* and Peigen Xiao 1,2
Institute of Medicinal Plant Development, Chinese Academy of Medical Science, Peking Union Medical College, Beijing 100193, China
Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing 100193, China
School of Graduate, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
School of Pharmacy, Anhui Medical University, Hefei 230032, China
School of Pharmacy, Baotou Medical College, Baotou 014060, China
Authors to whom correspondence should be addressed.
Molecules 2017, 22(12), 2050;
Received: 11 October 2017 / Revised: 14 November 2017 / Accepted: 21 November 2017 / Published: 24 November 2017
(This article belongs to the Section Natural Products Chemistry)
Resveratrol oligomers (REVs), a major class of stilbenoids, are biosynthesized by regioselective oxidative coupling of two to eight units of resveratrol monomer. Due to their unique structures and pleiotropic biological activities, natural product chemists are increasingly focusing on REVs in the last few decades. This study presents a detailed and thorough examination of REVs, including chemical structures, natural resources, and biological activities, during the period of 2010–2017. Ninety-two new REVs compounds, including 39 dimers, 23 trimers, 13 tetramers, six resveratrol monomers, six hexamers, four pentamers, and one octamer, have been reported from the families of Dipterocarpaceae, Paeoniaceae, Vitaceae, Leguminosae, Gnetaceae, Cyperaceae, Polygonaceae Gramineae, and Poaceae. Amongst these families, Dipterocarpaceae, with 50 REVs, accounts for the majority, and seven genera of Dipterocarpaceae are involved, including Vatica, Vateria, Shorea, Hopea, Neobalanocarpus, Dipterocarpus, and Dryobalanops. These REVs have shown a wide range of bioactivities. Pharmacological studies have mainly focused on potential efficacy on tumors, bacteria, Alzheimer’s disease, cardiovascular diseases, and others. The information updated in this review might assist further research and development of novel REVs as potential therapeutic agents. View Full-Text
Keywords: resveratrol oligomers; distribution; phytochemistry; pharmacology resveratrol oligomers; distribution; phytochemistry; pharmacology
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Shen, J.; Zhou, Q.; Li, P.; Wang, Z.; Liu, S.; He, C.; Zhang, C.; Xiao, P. Update on Phytochemistry and Pharmacology of Naturally Occurring Resveratrol Oligomers. Molecules 2017, 22, 2050.

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