Novel Bioactive Paulomycin Derivatives Produced by Streptomyces albus J1074
AbstractFour novel paulomycin derivatives have been isolated from S. albus J1074 grown in MFE culture medium. These compounds are structural analogs of antibiotics 273a2α and 273a2β containing a thiazole moiety, probably originated through an intramolecular Michael addition. The novel, thiazole, moiety-containing paulomycins show a lower antibiotic activity than paulomycins A and B against Gram-positive bacteria. However, two of them show an improved activity against Gram-negative bacteria. In addition, the four novel compounds are more stable in culture than paulomycins A and B. Thus, the presence of an N-acetyl-l-cysteine moiety linked to the carbon atom of the paulic acid isothiocyanate moiety, via a thioester bond, and the subsequent intramolecular cyclization of the paulic acid to generate a thiazole heterocycle confer to paulomycins a higher structural stability that otherwise will conduce to paulomycin degradation and into inactive paulomenols. View Full-Text
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Hoz, J.-D.; Méndez, C.; Salas, J.A.; Olano, C. Novel Bioactive Paulomycin Derivatives Produced by Streptomyces albus J1074. Molecules 2017, 22, 1758.
Hoz J-D, Méndez C, Salas JA, Olano C. Novel Bioactive Paulomycin Derivatives Produced by Streptomyces albus J1074. Molecules. 2017; 22(10):1758.Chicago/Turabian Style
Hoz, Jorge Fernández-De la; Méndez, Carmen; Salas, José A.; Olano, Carlos. 2017. "Novel Bioactive Paulomycin Derivatives Produced by Streptomyces albus J1074." Molecules 22, no. 10: 1758.
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