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Open AccessArticle

Synthesis, Characterization, and Biological Evaluations of 1,3,5-Triazine Derivatives of Metformin Cyclization with Berberine and Magnolol in the Presence of Sodium Methylate

1
Central Laboratory of Guangdong, Pharmaceutical University, Guangzhou 510000, China
2
College of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou 510000, China
*
Authors to whom correspondence should be addressed.
Molecules 2017, 22(10), 1752; https://doi.org/10.3390/molecules22101752
Received: 29 September 2017 / Accepted: 16 October 2017 / Published: 18 October 2017
(This article belongs to the Section Medicinal Chemistry)
The novel target products were synthesized in the formation of a triazine ring from berberine, magnolol, and metformin catalyzed by sodium methylate. The structures of products 13 were firstly confirmed by extensive spectroscopic analyses and single-crystal X-ray diffraction. The crystal structures of the target product 2 and the intermediate product 7b were reported for the first time. All target products were evaluated for their anti-inflammatory and antidiabetic activities against INS-1 and RAW264.1 cells in vitro and all products showed excellent anti-inflammatory effects and anti-insulin resistance effects. Our studies indicated that new compounds 13 were found to be active against inflammation and insulin resistance. View Full-Text
Keywords: cyclization triazine; anti-inflammatory activity; anti-insulin resistance cyclization triazine; anti-inflammatory activity; anti-insulin resistance
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MDPI and ACS Style

Cao, H.; Liao, S.; Zhong, W.; Xiao, X.; Zhu, J.; Li, W.; Wu, X.; Feng, Y. Synthesis, Characterization, and Biological Evaluations of 1,3,5-Triazine Derivatives of Metformin Cyclization with Berberine and Magnolol in the Presence of Sodium Methylate. Molecules 2017, 22, 1752.

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