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Molecules 2017, 22(1), 78;

The Hammerhead Ribozyme: A Long History for a Short RNA

Instituto de Biología Molecular y Celular de Plantas (IBMCP) (CSIC-UPV), C/Ingeniero Fausto Elio s/n, 46022 Valencia, Spain
Department of Genetics, University of Valencia, C/Dr. Moliner 50, Burjassot, 46100 Valencia, Spain
Author to whom correspondence should be addressed.
Academic Editor: Sabine Müller
Received: 30 November 2016 / Revised: 28 December 2016 / Accepted: 29 December 2016 / Published: 4 January 2017
(This article belongs to the Special Issue Ribozymes and RNA Catalysis)
Full-Text   |   PDF [2366 KB, uploaded 4 January 2017]   |  


Small nucleolytic ribozymes are a family of naturally occurring RNA motifs that catalyse a self-transesterification reaction in a highly sequence-specific manner. The hammerhead ribozyme was the first reported and the most extensively studied member of this family. However, and despite intense biochemical and structural research for three decades since its discovery, the history of this model ribozyme seems to be far from finished. The hammerhead ribozyme has been regarded as a biological oddity typical of small circular RNA pathogens of plants. More recently, numerous and new variations of this ribozyme have been found to inhabit the genomes of organisms from all life kingdoms, although their precise biological functions are not yet well understood. View Full-Text
Keywords: phosphodiester bond; RNA catalysis; self-cleaving phosphodiester bond; RNA catalysis; self-cleaving

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de la Peña, M.; García-Robles, I.; Cervera, A. The Hammerhead Ribozyme: A Long History for a Short RNA. Molecules 2017, 22, 78.

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