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Molecules 2017, 22(1), 46;

Synthesis and Single Crystal Structures of Substituted-1,3-Selenazol-2-amines

EaStCHEM School of Chemistry, University of St. Andrews, St. Andrews, Fife KY16 9ST, UK
Dedication: This paper is dedicated to Prof. Eva Marie Hey-Hawkins on the occasion of her 60th birthday.
Author to whom correspondence should be addressed.
Academic Editors: Claudio Santi and Luana Bagnoli
Received: 15 December 2016 / Revised: 23 December 2016 / Accepted: 26 December 2016 / Published: 29 December 2016
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The synthesis and X-ray single crystal structures of a series of new 4-substituted-1,3-selenazol-2-amines is reported. The efficient preparation of these compounds was carried out by two-component cyclization of the selenoureas with equimolar amounts of α-haloketones. The selenoureas were obtained from the reaction of Woollins’ reagent with cyanamides, followed by hydrolysis with water. All new compounds have been characterized by IR spectroscopy, multi-NMR (1H, 13C, 77Se) spectroscopy, accurate mass measurement and single crystal X-ray structure analysis. View Full-Text
Keywords: cyanamides; haloketones; selenazol-2-amines; selenoureas; Woollins’ reagent cyanamides; haloketones; selenazol-2-amines; selenoureas; Woollins’ reagent

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Hua, G.; Du, J.; Slawin, A.M.Z.; Woollins, J.D. Synthesis and Single Crystal Structures of Substituted-1,3-Selenazol-2-amines. Molecules 2017, 22, 46.

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