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Plant Cell Cancer: May Natural Phenolic Compounds Prevent Onset and Development of Plant Cell Malignancy? A Literature Review

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Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah 6714967346, Iran
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Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah 6714967346, Iran
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Nano Drug Delivery Research Center, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah 6714967346, Iran
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Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Molecules 2016, 21(9), 1104; https://doi.org/10.3390/molecules21091104
Received: 11 July 2016 / Revised: 3 August 2016 / Accepted: 8 August 2016 / Published: 23 August 2016
(This article belongs to the Section Natural Products Chemistry)
Phenolic compounds (PCs) are known as a chemically diverse category of secondary and reactive metabolites which are produced in plants via the shikimate-phenylpropanoid pathways. These compounds—ubiquitous in plants—are an essential part of the human diet, and are of considerable interest due to their antioxidant properties. Phenolic compounds are essential for plant functions, because they are involved in oxidative stress reactions, defensive systems, growth, and development. A large body of cellular and animal evidence carried out in recent decades has confirmed the anticancer role of PCs. Phytohormones—especially auxins and cytokinins—are key contributors to uncontrolled growth and tumor formation. Phenolic compounds can prevent plant growth by the endogenous regulation of auxin transport and enzymatic performance, resulting in the prevention of tumorigenesis. To conclude, polyphenols can reduce plant over-growth rate and the development of tumors in plant cells by regulating phytohormones. Future mechanistic studies are necessary to reveal intracellular transcription and transduction agents associated with the preventive role of phenolics versus plant pathological malignancy cascades. View Full-Text
Keywords: phenolic compounds; flavonoids; cancer; secondary metabolites phenolic compounds; flavonoids; cancer; secondary metabolites
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MDPI and ACS Style

Rasouli, H.; Farzaei, M.H.; Mansouri, K.; Mohammadzadeh, S.; Khodarahmi, R. Plant Cell Cancer: May Natural Phenolic Compounds Prevent Onset and Development of Plant Cell Malignancy? A Literature Review. Molecules 2016, 21, 1104.

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