Next Article in Journal
Design and Stereochemical Research (DFT, ECD and Crystal Structure) of Novel Bedaquiline Analogs as Potent Antituberculosis Agents
Next Article in Special Issue
Design, Synthesis and Biological Evaluation of Benzohydrazide Derivatives Containing Dihydropyrazoles as Potential EGFR Kinase Inhibitors
Previous Article in Journal
Controlled Release of Nor-β-lapachone by PLGA Microparticles: A Strategy for Improving Cytotoxicity against Prostate Cancer Cells
Previous Article in Special Issue
Molecular Dynamics Simulations to Investigate the Binding Mode of the Natural Product Liphagal with Phosphoinositide 3-Kinase α
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Molecules
Volume 21
Issue 7
10.3390/molecules21070876
molecules-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Design, Synthesis and Biological Evaluation of Novel Benzothiazole Derivatives as Selective PI3Kβ Inhibitors

by
Shuang Cao
1,2,†,
Ruiyuan Cao
1,†,
Xialing Liu
2,
Xiang Luo
2 and
Wu Zhong
1,*
1
Laboratory of Computer-Aided Drug Design & Discovery, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China
2
Hubei Key Laboratory of Novel Chemical Reactor and Green Chemical Technology, Wuhan Institute of Technology, Wuhan 430073, Hubei, China
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Molecules 2016, 21(7), 876; https://doi.org/10.3390/molecules21070876
Submission received: 5 June 2016 / Revised: 22 June 2016 / Accepted: 24 June 2016 / Published: 2 July 2016
(This article belongs to the Special Issue Kinase Inhibitor Chemistry)
Browse Figures
Versions Notes

Abstract

A novel series of PI3Kβ (Phosphatidylinositol-3-kinases beta subunit) inhibitors with the structure of benzothiazole scaffold have been designed and synthesized. All the compounds have been evaluated for inhibitory activities against PI3Kα, β, γ, δ and mTOR (Mammalian target of rapamycin). Two superior compounds have been further evaluated for the IC50 values against PI3Ks/mTOR. The most promising compound 11 displays excellent anti-proliferative activity and selectivity in multiple cancer cell lines, especially in the prostate cancer cell line. Docking studies indicate the morpholine group in 2-position of benzothiazole is necessary for the potent antitumor activity, which confirms our design is reasonable.
Keywords: PI3Kβ; mTOR; kinase inhibitor; docking PI3Kβ; mTOR; kinase inhibitor; docking
Graphical Abstract

Share and Cite

MDPI and ACS Style

Cao, S.; Cao, R.; Liu, X.; Luo, X.; Zhong, W. Design, Synthesis and Biological Evaluation of Novel Benzothiazole Derivatives as Selective PI3Kβ Inhibitors. Molecules 2016, 21, 876. https://doi.org/10.3390/molecules21070876

AMA Style

Cao S, Cao R, Liu X, Luo X, Zhong W. Design, Synthesis and Biological Evaluation of Novel Benzothiazole Derivatives as Selective PI3Kβ Inhibitors. Molecules. 2016; 21(7):876. https://doi.org/10.3390/molecules21070876

Chicago/Turabian Style

Cao, Shuang, Ruiyuan Cao, Xialing Liu, Xiang Luo, and Wu Zhong. 2016. "Design, Synthesis and Biological Evaluation of Novel Benzothiazole Derivatives as Selective PI3Kβ Inhibitors" Molecules 21, no. 7: 876. https://doi.org/10.3390/molecules21070876

APA Style

Cao, S., Cao, R., Liu, X., Luo, X., & Zhong, W. (2016). Design, Synthesis and Biological Evaluation of Novel Benzothiazole Derivatives as Selective PI3Kβ Inhibitors. Molecules, 21(7), 876. https://doi.org/10.3390/molecules21070876

Article Metrics

Back to TopTop