Next Article in Journal
Antioxidative, Antibacterial, and Food Functional Properties of the Half-Fin Anchovy Hydrolysates-Glucose Conjugates Formed via Maillard Reaction
Next Article in Special Issue
Capsaicin Synthesis Requires in Situ Phenylalanine and Valine Formation in in Vitro Maintained Placentas from Capsicum chinense
Previous Article in Journal
The Deformation of Polydimethylsiloxane (PDMS) Microfluidic Channels Filled with Embedded Circular Obstacles under Certain Circumstances
Previous Article in Special Issue
Capsaicin Inhibited Aggressive Phenotypes through Downregulation of Tumor-Associated NADH Oxidase (tNOX) by POU Domain Transcription Factor POU3F2
Open AccessReview

Capsaicin, Nociception and Pain

1
Department of Integrative Medical Biology, University of Umea, 901 87 Umea, Sweden
2
Department of Veterinary Sciences, University of Turin, Largo Paolo Braccini 2, I-10095 Grugliasco (TO), Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Pin Ju Chueh
Molecules 2016, 21(6), 797; https://doi.org/10.3390/molecules21060797
Received: 29 April 2016 / Revised: 6 June 2016 / Accepted: 14 June 2016 / Published: 18 June 2016
(This article belongs to the Special Issue Capsaicin)
Capsaicin, the pungent ingredient of the hot chili pepper, is known to act on the transient receptor potential cation channel vanilloid subfamily member 1 (TRPV1). TRPV1 is involved in somatic and visceral peripheral inflammation, in the modulation of nociceptive inputs to spinal cord and brain stem centers, as well as the integration of diverse painful stimuli. In this review, we first describe the chemical and pharmacological properties of capsaicin and its derivatives in relation to their analgesic properties. We then consider the biochemical and functional characteristics of TRPV1, focusing on its distribution and biological effects within the somatosensory and viscerosensory nociceptive systems. Finally, we discuss the use of capsaicin as an agonist of TRPV1 to model acute inflammation in slices and other ex vivo preparations. View Full-Text
Keywords: capsaicin; vanilloids; TRPV1 receptor; nociception; somatic pain; visceral pain; sensitization; analgesia; resinferatoxin capsaicin; vanilloids; TRPV1 receptor; nociception; somatic pain; visceral pain; sensitization; analgesia; resinferatoxin
Show Figures

Figure 1

MDPI and ACS Style

Frias, B.; Merighi, A. Capsaicin, Nociception and Pain. Molecules 2016, 21, 797. https://doi.org/10.3390/molecules21060797

AMA Style

Frias B, Merighi A. Capsaicin, Nociception and Pain. Molecules. 2016; 21(6):797. https://doi.org/10.3390/molecules21060797

Chicago/Turabian Style

Frias, Bárbara; Merighi, Adalberto. 2016. "Capsaicin, Nociception and Pain" Molecules 21, no. 6: 797. https://doi.org/10.3390/molecules21060797

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop