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Molecules 2016, 21(4), 523;

Glycyrrhetic Acid Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Vivo

Department of Oriental Medicine Resources, Chonbuk National University, 79 Gobongro, Iksan 570-752(1), Korea
Department of Pharmacy, College of Pharmacy, Dongduk Woman’s University, 23-1 Wolgok-Dong, SungBuk-Gu, Seoul 136-714, Korea
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 25 January 2016 / Revised: 13 April 2016 / Accepted: 14 April 2016 / Published: 22 April 2016
(This article belongs to the Section Natural Products Chemistry)
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Glycyrrhizae Radix (GR) is a Korean traditional herb medicine that is widely used in clinical health care. Glycyrrhetic acid (GA) is an aglycone saponin extracted from GR that has anti-inflammatory, anti-cancer, and anti-viral effects. However, the anti-inflammatory effects of GA in colitis have not been reported. This study investigated the role of GA on ulcerative colitis in a dextran sulfate sodium (DSS)-induced mouse colitis model. DSS-treated mice displayed weight loss and shortened colon length compared with control mice. Mice administered GA showed less weight loss and longer colon length than the DSS-treated group. Interleukin (IL)-6, IL-1β, and tumor necrosis factor-alpha were decreased by GA treatment. GA treatment also reduced DSS-induced microscopic damage to colon tissue. GA regulates the phosphorylation of transcription factors including nuclear factor-kappa B (NF-κB) and IκB alpha, and regulates the expression of cycloxygenase-2 and prostaglandin E2. GA thus showed beneficial effects in a mouse model of colitis, implicating GA might be a useful herb-derived medicine in the treatment of ulcerative colitis. View Full-Text
Keywords: glycyrrhetic acid; ulcerative colitis; dextran sulfate sodium; anti-inflammation glycyrrhetic acid; ulcerative colitis; dextran sulfate sodium; anti-inflammation

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Jeon, Y.-D.; Kang, S.-H.; Bang, K.-S.; Chang, Y.-N.; Lee, J.-H.; Jin, J.-S. Glycyrrhetic Acid Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Vivo. Molecules 2016, 21, 523.

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