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Molecules 2016, 21(3), 299;

Synthesis of New Bis(3-hydroxy-4-pyridinone) Ligands as Chelating Agents for Uranyl Complexation

State Key Laboratory Cultivation Base for Nonmetal Composites and Functional Materials, Southwest University of Science and Technology, Mianyang 621010, China
Authors to whom correspondence should be addressed.
Academic Editor: Wim Dehaen
Received: 22 January 2016 / Revised: 19 February 2016 / Accepted: 23 February 2016 / Published: 8 March 2016
(This article belongs to the Section Medicinal Chemistry)
Full-Text   |   PDF [815 KB, uploaded 8 March 2016]   |  


Five new bis(3-hydroxy-4-pyridinone) tetradentate chelators were synthesized in this study. The structures of these tetradentate chelators were characterized by 1H-NMR, 13C-NMR, FT-IR, UV-vis, and mass spectral analyses. The binding abilities of these tetradentate chelators for uranyl ion at pH 7.4 were also determined by UV spectrophotometry in aqueous media. Results showed that the efficiencies of these chelating agents are dependent on the linker length. Ligand 4b is the best chelator and suitable for further studies. View Full-Text
Keywords: chelating agent; 3-hydroxy-4-pyridinone; uranium; tetradentate chelator chelating agent; 3-hydroxy-4-pyridinone; uranium; tetradentate chelator

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Jin, B.; Zheng, R.; Peng, R.; Chu, S. Synthesis of New Bis(3-hydroxy-4-pyridinone) Ligands as Chelating Agents for Uranyl Complexation. Molecules 2016, 21, 299.

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