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Open AccessReview

Natural Products from Chinese Medicines with Potential Benefits to Bone Health

Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The University of Illinois at Chicago, Chicago, IL 60612, USA
Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, China
State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Macau, China
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Molecules 2016, 21(3), 239;
Received: 9 December 2015 / Revised: 3 February 2016 / Accepted: 12 February 2016 / Published: 27 February 2016
(This article belongs to the Collection Herbal Medicine Research)
Osteoporosis is a progressive, systemic bone disorder characterized by loss of bone mass and microstructure, leading to reduced bone strength and increased risk of fracture. It is often associated with reduced quality of life and other medical complications. The disease is common in the aging population, particularly among postmenopausal women and patients who receive long-term steroidal therapy. Given the rapid growth of the aging population, increasing life expectancy, the prevalence of bone loss, and financial burden to the healthcare system and individuals, demand for new therapeutic agents and nutritional supplements for the management and promotion of bone health is pressing. With the advent of global interest in complementary and alternative medicine and natural products, Chinese medicine serves as a viable source to offer benefits for the improvement and maintenance of bone health. This review summarizes the scientific information obtained from recent literatures on the chemical ingredients of Chinese medicinal plants that have been reported to possess osteoprotective and related properties in cell-based and/or animal models. Some of these natural products (or their derivatives) may become promising leads for development into dietary supplements or therapeutic drugs. View Full-Text
Keywords: anti-osteoporosis; osteoprotection; bone health; natural product; Chinese medicine anti-osteoporosis; osteoprotection; bone health; natural product; Chinese medicine
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Che, C.-T.; Wong, M.S.; Lam, C.W.K. Natural Products from Chinese Medicines with Potential Benefits to Bone Health. Molecules 2016, 21, 239.

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