Next Article in Journal
Cryptolepine, a Plant Alkaloid, Inhibits the Growth of Non-Melanoma Skin Cancer Cells through Inhibition of Topoisomerase and Induction of DNA Damage
Next Article in Special Issue
Hydrogen Sulfide in the Adipose Tissue—Physiology, Pathology and a Target for Pharmacotherapy
Previous Article in Journal
Hypervalent Iodine(III)-Induced Domino Oxidative Cyclization for the Synthesis of Cyclopenta[b]furans
Previous Article in Special Issue
Redox Signaling Regulated by Cysteine Persulfide and Protein Polysulfidation
Open AccessReview

Sulfur Atom in its Bound State Is a Unique Element Involved in Physiological Functions in Mammals

Department of Analytical Biochemistry, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan
Author to whom correspondence should be addressed.
Academic Editors: Noriyuki Nagahara and Derek J. McPhee
Molecules 2016, 21(12), 1753;
Received: 18 October 2016 / Revised: 12 December 2016 / Accepted: 15 December 2016 / Published: 21 December 2016
(This article belongs to the Special Issue Sulfur Atom: Element for Adaptation to an Oxidative Environment 2016)
It was in the 1950s that the term polysulfide or persulfide was introduced in biological studies. The unfamiliar term “sulfane sulfur” sometimes appeared in papers published in the 1970s, and was defined in the review article by Westley in 1983. In the article, sulfane sulfur is described as sulfur atoms that are covalently bound only with sulfur atoms, and as this explanation was somewhat difficult to comprehend, it was not generally accepted. Thus, in the early 1990s, we redefined these sulfur species as “bound sulfur”, which easily converts to hydrogen sulfide on reduction with a thiol reducing agent. In other words, bound sulfur refers to a sulfur atom that exists in a zero to divalent form (0 to −2). The first part of this review focuses on the fluorescent derivatization HPLC method—which we developed for measurement of bound sulfur—and explains the distribution of bound sulfur and the hydrogen sulfide-producing ability of various tissues, as clarified by this method. Next, we discuss diverse physiological functions and involvement of polysulfide, a typical type of bound sulfur, in the redox regulation system. Additionally, we also address its possible physiological role in the central nervous system, based on its action of scavenging reactive carbonyl compounds. View Full-Text
Keywords: bound sulfur; hydrogen sulfide; oxidative stress; persulfide; polysulfides bound sulfur; hydrogen sulfide; oxidative stress; persulfide; polysulfides
Show Figures

Figure 1

MDPI and ACS Style

Koike, S.; Ogasawara, Y. Sulfur Atom in its Bound State Is a Unique Element Involved in Physiological Functions in Mammals. Molecules 2016, 21, 1753.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop