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Antimicrobial Activity and Urease Inhibition of Schiff Bases Derived from Isoniazid and Fluorinated Benzaldehydes and of Their Copper(II) Complexes

1
Department of Chemical Theory of Drugs, Faculty of Pharmacy, Comenius University, Kalinčiakova 8, SK-832 32 Bratislava, Slovakia
2
Department of Cellular and Molecular Biology of Drugs, Faculty of Pharmacy, Comenius University, Kalinčiakova 8, SK-832 32 Bratislava, Slovakia
3
Department of Physical Chemistry, Faculty of Chemical and Food Technology, Slovak University of Technology, Radlinského 9, SK-812 37 Bratislava, Slovakia
*
Author to whom correspondence should be addressed.
Academic Editor: Patrick Gamez
Molecules 2016, 21(12), 1742; https://doi.org/10.3390/molecules21121742
Received: 13 November 2016 / Revised: 6 December 2016 / Accepted: 13 December 2016 / Published: 17 December 2016
(This article belongs to the Special Issue Metal Based Drugs: Opportunities and Challenges)
In order to evaluate the influence of substitution on biological properties of Schiff bases and their metal complexes, a series of differently substituted fluorine-containing Schiff bases starting from the drug isoniazid (isonicotinylhydrazide) were prepared and their structures were established by single-crystal X-ray diffraction. Also, four copper(II) complexes of these Schiff bases were synthesized. The prepared compounds were evaluated for their antimicrobial activity and urease inhibition. Two of the Schiff bases exerted activity against C. albicans. All copper(II) complexes showed excellent inhibitory properties against jack bean urease, considerably better than that of the standard inhibitor acetohydroxamic acid. View Full-Text
Keywords: copper(II) complexes; urease inhibitors; antimicrobial activity; fluorine; isoniazid copper(II) complexes; urease inhibitors; antimicrobial activity; fluorine; isoniazid
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MDPI and ACS Style

Habala, L.; Varényi, S.; Bilková, A.; Herich, P.; Valentová, J.; Kožíšek, J.; Devínsky, F. Antimicrobial Activity and Urease Inhibition of Schiff Bases Derived from Isoniazid and Fluorinated Benzaldehydes and of Their Copper(II) Complexes. Molecules 2016, 21, 1742.

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