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Open AccessArticle

Polyphenols Isolated from Xanthoceras sorbifolia Husks and Their Anti-Tumor and Radical-Scavenging Activities

1
CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China
2
School of Pharmacy, Institute of Materia Medica, North Sichuan Medical College, Nanchong 637007, China
3
Department of Preventive Medicine, North Sichuan Medical College, Nanchong 637007, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Jean-Marc Sabatier
Molecules 2016, 21(12), 1694; https://doi.org/10.3390/molecules21121694
Received: 21 October 2016 / Revised: 4 December 2016 / Accepted: 6 December 2016 / Published: 9 December 2016
(This article belongs to the Special Issue Structure-Activity Relationship of Natural Products)
Xanthoceras sorbifolia Bunge. is used in traditional medicine in North China. To evaluate the anti-tumor and radical-scavenging activities of X. sorbifolia husks polyphenols and determine their structure-activity relationships, 37 polyphenols 137 were obtained by bioassay-guided fractionation. Two new compounds 12, and compounds 5, 6, 8, 9, 11, 1417, 2125, 2729, 31, 33, 34, 36, and 37 were isolated from the genus Xanthoceras for the first time. Compounds 137 did not show strong cytotoxicity against the four tested tumor cell lines (A549, HepG2, MGC-803, and MFC) compared to paclitaxel and under the conditions tested in the anti-tumor assay, but compounds 3, 4, 7, 8, 10, 1820, 25, 26, 29, 30, 32, and 35 exhibited stronger radical-scavenging activity than ascorbic acid in a 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt assay. This was the first report on the anti-tumor and radical-scavenging activities of the polyphenols isolated from X. sorbifolia husks. Overall, the present study contributed valuable information concerning X. sorbifolia husks use in medicine and pharmacology. View Full-Text
Keywords: Xanthoceras sorbifolia; polyphenols; extracts; anti-tumor activity; radical-scavenging activity Xanthoceras sorbifolia; polyphenols; extracts; anti-tumor activity; radical-scavenging activity
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MDPI and ACS Style

Yang, C.-Y.; Ha, W.; Lin, Y.; Jiang, K.; Yang, J.-L.; Shi, Y.-P. Polyphenols Isolated from Xanthoceras sorbifolia Husks and Their Anti-Tumor and Radical-Scavenging Activities. Molecules 2016, 21, 1694.

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