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Molecules 2016, 21(11), 1556;

Cyclic Glucans Enhance Solubility of Bioavailable Flavonoids

Department of Applied Chemistry, Dongduk Women’s University, Seoul 136-714, Korea
Academic Editor: Derek J. McPhee
Received: 26 October 2016 / Revised: 14 November 2016 / Accepted: 15 November 2016 / Published: 16 November 2016
(This article belongs to the Section Bioorganic Chemistry)
Full-Text   |   PDF [2906 KB, uploaded 16 November 2016]   |  


Diverse flavonoids are abundant in dietary food constituents and possess useful biological activities. However, some flavonoids have limited bioavailability due to their low solubility in water. As an important approach to enhance aqueous solubility, inclusion of hydrophobic guest molecules in hydrophilic hosts such as cyclic glucans has been used. This review summarizes applications of β-cyclodextrin, synthetic β-cyclodextrin derivatives, and newly synthesized derivatives of cyclosophoraoses as complexing agents to enhance the bioavailability of flavonoids such as baicalein, kaempferol, and naphthoflavones. View Full-Text
Keywords: β-cyclodextrin; cyclosophoraoses; flavonoid; inclusion complex; bioavailability β-cyclodextrin; cyclosophoraoses; flavonoid; inclusion complex; bioavailability

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Park, S. Cyclic Glucans Enhance Solubility of Bioavailable Flavonoids. Molecules 2016, 21, 1556.

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