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Molecules 2016, 21(10), 1378;

The Inhibition Effect of Cell DNA Oxidative Damage and LDL Oxidation by Bovine Colostrums

Department of Health Food, Chung Chou University of Science and Technology, Changhua 51591, Taiwan
Department of Health and Creative Vegetarian Science, Fo Guang University, No. 160, Linwei Rd., Jiaosi, Yilan County 26247, Taiwan
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 11 August 2016 / Revised: 4 October 2016 / Accepted: 19 October 2016 / Published: 21 October 2016
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In the present study, we investigated the effect of bovine colostrums on inhibition of DNA oxidative damage and low density lipoprotein (LDL) oxidation in vitro. Results showed that whey and skimmed milk exhibited not only higher inhibitory activities of oxidative damage of deoxyribose but also an inhibitory effect on the breakdown of supercoiled DNA into open circular DNA and linear DNA. The quantities of 8-OH-2′-dG formed under whey, caseins and skimmed milk treatment were 0.24, 0.24 and 1.24 μg/mL, respectively. The quantity of malondialdehyde formed through LDL oxidation induced by copprous ion was significantly decreased as colostrums protein solutions were added, in which whey and caseins led to a more significant decrease than skimmed milk. The formation of conjugated dienes could be inhibited by treatment with colostrums protein solutions. Whey exhibited the longest lag time of conjugated dienes formation among the colostrums proteins. The lag time of the whey was 2.33 times that of the control. From the results of foregoing, the bovine colostrums protein has potential value in the inhibition of DNA oxidation damage and LDL oxidation. View Full-Text
Keywords: bovine colostrum; DNA oxidative damage; low density lipoprotein (LDL); LDL oxidation bovine colostrum; DNA oxidative damage; low density lipoprotein (LDL); LDL oxidation

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Chen, C.-W.; Chang, C.-Y.; Chiang, S.-H. The Inhibition Effect of Cell DNA Oxidative Damage and LDL Oxidation by Bovine Colostrums. Molecules 2016, 21, 1378.

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