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Molecules 2015, 20(9), 17166-17179;

Blumea balsamifera Oil for the Acceleration of Healing of Burn Injuries

1,3,4,* , 1,3,4
1,3,4,* , 2
Tropical Crops Genetic Resources Institute, Chinese Academy of Tropical Agricultural Sciences, Danzhou 571737, China
School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China
Key Laboratory of Crop Gene Resources and Germplasm Enhancement in Southern China, Danzhou 571737, China
Hainan Provincial Engineering Research Center for Blumea balsamifera, Danzhou 571737, China
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 12 June 2015 / Revised: 2 September 2015 / Accepted: 14 September 2015 / Published: 17 September 2015
(This article belongs to the Section Medicinal Chemistry)
Full-Text   |   PDF [5307 KB, uploaded 17 September 2015]   |  


Blumea balsamifera oil (BBO) is a main extract obtained from Blumea balsamifera (L.) DC (Ainaxiang) leaves, which are widely used as a traditional medicine by the Miao and Li Nations to promote skin trauma or burn injury healing. This study was initiated to investigate the healing efficacy in deep second-degree burn model in rats. The rats were treated by BBO for 21 consecutive days. The rate of healing, scabs dropped time and re-epithelialization time were observed every three days for 21 days after burn injury. The samples were collected from different treated rats by sacrificing the animals on the 1st, 2nd, 5th, 9th, 14th, and 21st day post-burn creation. Then, the water content of burn tissue was measured. Plasma interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-α) levels were evaluated, and the tissue expressions of basic fibroblast growth factor (bFGF), vascular endothelial growth factor (VEGF), and transforming growth factor-beta (TGF-β) were determined along with skin histopathology. The results showed that the water content of tissue was significantly reduced, the scabs dropped time shortened, and healing accelerated after treatment with BBO in the burn injury rats. Furthermore, the expressions of growth factors were significantly increased in the tissue; however, the levels of inflammatory factors on plasma decreased. This study confirms the efficacy of BBO consumption on burn injuries. View Full-Text
Keywords: Blumea balsamifera (L.) oil (BBO); deep second-degree burn; inflammatory factor; cytokine; growth factor Blumea balsamifera (L.) oil (BBO); deep second-degree burn; inflammatory factor; cytokine; growth factor

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Fan, Z.-W.; Pang, Y.-X.; Wang, K.; Yu, F.-L.; Wang, D.; Yang, Q.; Ma, Q.-S.; Li, X.-T.; Zou, J.; Zhang, W.-Q.; Wu, L.-F. Blumea balsamifera Oil for the Acceleration of Healing of Burn Injuries. Molecules 2015, 20, 17166-17179.

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