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Molecules 2015, 20(8), 15330-15342;

α-Glucosidase Inhibitors from Vauquelinia corymbosa

Facultad de Química, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico
Instituto de Biología, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico
Author to whom correspondence should be addressed.
Academic Editor: Isabel C. F. R. Ferreira
Received: 4 July 2015 / Revised: 15 August 2015 / Accepted: 18 August 2015 / Published: 21 August 2015
(This article belongs to the Collection Bioactive Compounds)
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The α-glucosidase inhibitory activity of an aqueous extract and compounds from the aerial parts of V. corymbosa was demonstrated with yeast and rat small intestinal α-glucosidases. The aqueous extract inhibited yeast α-glucosidase with a half maximal inhibitory concentration (IC50) of 28.6 μg/mL. Bioassay-guided fractionation of the extract led to the isolation of several compounds, including one cyanogenic glycoside [prunasin (1)], five flavonoids [(−)-epi-catechin (2), hyperoside (3), isoquercetin (4), quercitrin (5) and quercetin-3-O-(6′′-benzoyl)-β-galactoside (6)] and two simple aromatic compounds [picein (7) and methylarbutin (8)]. The most active compound was 6 with IC50 values of 30 μM in the case of yeast α-glucosidase, and 437 μM in the case of the mammalian enzyme. According to the kinetic analyses performed with rat and yeast enzymes, this compound behaved as mixed-type inhibitor; the calculated inhibition constants (Ki) were 212 and 50 μM, respectively. Molecular docking analyses with yeast and mammalian α-glucosidases revealed that compound 6 bind differently to these enzymes. Altogether, the results of this work suggest that preparations of V. corymbosa might delay glucose absorption in vivo. View Full-Text
Keywords: diabetes; yeast and rat α-glucosidases; Vauquelinia corymbosa diabetes; yeast and rat α-glucosidases; Vauquelinia corymbosa

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Flores-Bocanegra, L.; Pérez-Vásquez, A.; Torres-Piedra, M.; Bye, R.; Linares, E.; Mata, R. α-Glucosidase Inhibitors from Vauquelinia corymbosa. Molecules 2015, 20, 15330-15342.

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