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Open AccessArticle

Oral Intake of Carboxymethyl-Glucan (CM-G) from Yeast (Saccharomyces uvarum) Reduces Malondialdehyde Levels in Healthy Men

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Laboratório de Bioquímica de Alimentos, Departamento de Engenharia de Alimentos, Universidade Federal da Paraíba, João Pessoa, Paraíba 58051-900, Brazil
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Departamento de Ciência e Tecnologia de Alimentos, Universidade Estadual de Londrina, Paraná 8606970, Brazil
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Departamento de Educação, Universidade Federal da Paraíba, João Pessoa, Paraíba 58051-900, Brazil
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Laboratório de Microbiologia de Alimentos, Departmento de Nutrição, Universidade Federal da Paraíba, João Pessoa, Paraíba 58051-900, Brazil
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Molecules 2015, 20(8), 14950-14958; https://doi.org/10.3390/molecules200814950
Received: 20 June 2015 / Revised: 10 August 2015 / Accepted: 12 August 2015 / Published: 14 August 2015
(This article belongs to the Section Medicinal Chemistry)
Carboxymethyl-glucan (CM-G) is a water-soluble derivative of β(1→3)(1→6) glucan, a well-known immunostimulant and antioxidant compound. In this experimental, randomized and placebo-controlled study, the effects of oral CM-G intake over a 60-day period on the peripheral blood, cholesterol, glycemic index and malondialdehyde (MDA) levels of healthy men was assessed. The CM-G was obtained from spent brewer’s yeast (S. uvarum) with DS 0.8 and molecular weight of 2.2 × 105 Da. Following CM-G administration, no changes were observed in red and white blood cell, hematocrit, hemoglobin and platelet counts, or in cholesterol and glycemic indices. After 30 days of CM-G administration, the MDA levels decreased significantly (p ≤ 0.05) in men receiving CM-G. The results showed for the first time that CM-G may act as an adjuvant in preventing oxidative damage in healthy humans. View Full-Text
Keywords: carboxymethyl-glucan; glucan-derivatives; malondialdehyde; blood cells carboxymethyl-glucan; glucan-derivatives; malondialdehyde; blood cells
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MDPI and ACS Style

Araújo, V.B.d.S.; De Melo, A.N.F.; De Souza, N.T.; Da Silva, V.M.B.; Castro-Gomez, R.H.; Silva, A.S.; De Souza, E.L.; Magnani, M. Oral Intake of Carboxymethyl-Glucan (CM-G) from Yeast (Saccharomyces uvarum) Reduces Malondialdehyde Levels in Healthy Men. Molecules 2015, 20, 14950-14958. https://doi.org/10.3390/molecules200814950

AMA Style

Araújo VBdS, De Melo ANF, De Souza NT, Da Silva VMB, Castro-Gomez RH, Silva AS, De Souza EL, Magnani M. Oral Intake of Carboxymethyl-Glucan (CM-G) from Yeast (Saccharomyces uvarum) Reduces Malondialdehyde Levels in Healthy Men. Molecules. 2015; 20(8):14950-14958. https://doi.org/10.3390/molecules200814950

Chicago/Turabian Style

Araújo, Vilma B.d.S.; De Melo, Adma N.F.; De Souza, Neyrijane T.; Da Silva, Vânia M.B.; Castro-Gomez, Raul H.; Silva, Alexandre S.; De Souza, Evandro L.; Magnani, Marciane. 2015. "Oral Intake of Carboxymethyl-Glucan (CM-G) from Yeast (Saccharomyces uvarum) Reduces Malondialdehyde Levels in Healthy Men" Molecules 20, no. 8: 14950-14958. https://doi.org/10.3390/molecules200814950

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