Next Article in Journal
Synthesis of a Spirocyclic Oxetane-Fused Benzimidazole
Previous Article in Journal
Imaging the Ultrafast Photoelectron Transfer Process in Alizarin-TiO2
Article Menu

Export Article

Open AccessArticle
Molecules 2015, 20(8), 13854-13863; https://doi.org/10.3390/molecules200813854

Antiproliferative and Structure Activity Relationships of Amaryllidaceae Alkaloids

1
Instituto Universitario de Bio-Orgánica Antonio González (CIBICAN), Universidad de La Laguna, Av. Astrofísico Francisco Sánchez 2, La Laguna 38206, Spain
2
Departamento de Ingeniería Química Industrial, Universidad de Ingeniería & Tecnología (UTEC), Av. Cascanueces 2221 Santa Anita, Lima 43, Peru
3
Departamento de Química Orgánica, Universidad de La Laguna, La Laguna 38206, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 19 June 2015 / Revised: 23 July 2015 / Accepted: 27 July 2015 / Published: 30 July 2015
(This article belongs to the Section Natural Products Chemistry)
Full-Text   |   PDF [797 KB, uploaded 30 July 2015]   |  

Abstract

The antiproliferative activity of a set of seven natural Amaryllidaceae alkaloids and 32 derivatives against four cancer cell lines (A2780, SW1573, T47-D and WiDr) was determined. The best antiproliferative activities were achieved with alkaloids derived from pancracine (2), haemanthamine (6) and haemantidine (7). For each skeleton, some structure-activity relationships were outlined. View Full-Text
Keywords: Amarylidaceae alkaloids; antiproliferative activity; SAR Amarylidaceae alkaloids; antiproliferative activity; SAR
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Cedrón, J.C.; Ravelo, Á.G.; León, L.G.; Padrón, J.M.; Estévez-Braun, A. Antiproliferative and Structure Activity Relationships of Amaryllidaceae Alkaloids. Molecules 2015, 20, 13854-13863.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top