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Molecules 2015, 20(8), 13854-13863;

Antiproliferative and Structure Activity Relationships of Amaryllidaceae Alkaloids

Instituto Universitario de Bio-Orgánica Antonio González (CIBICAN), Universidad de La Laguna, Av. Astrofísico Francisco Sánchez 2, La Laguna 38206, Spain
Departamento de Ingeniería Química Industrial, Universidad de Ingeniería & Tecnología (UTEC), Av. Cascanueces 2221 Santa Anita, Lima 43, Peru
Departamento de Química Orgánica, Universidad de La Laguna, La Laguna 38206, Spain
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 19 June 2015 / Revised: 23 July 2015 / Accepted: 27 July 2015 / Published: 30 July 2015
(This article belongs to the Section Natural Products Chemistry)
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The antiproliferative activity of a set of seven natural Amaryllidaceae alkaloids and 32 derivatives against four cancer cell lines (A2780, SW1573, T47-D and WiDr) was determined. The best antiproliferative activities were achieved with alkaloids derived from pancracine (2), haemanthamine (6) and haemantidine (7). For each skeleton, some structure-activity relationships were outlined. View Full-Text
Keywords: Amarylidaceae alkaloids; antiproliferative activity; SAR Amarylidaceae alkaloids; antiproliferative activity; SAR

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Cedrón, J.C.; Ravelo, Á.G.; León, L.G.; Padrón, J.M.; Estévez-Braun, A. Antiproliferative and Structure Activity Relationships of Amaryllidaceae Alkaloids. Molecules 2015, 20, 13854-13863.

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