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Open AccessArticle

In Vivo Antihyperglycemic Activity of a Lanosteryl Triterpene from Protorhus longifolia

Department of Biochemistry and Microbiology, University of Zululand, Private Bag X1001, KwaDlangezwa 3886, South Africa
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Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Derek J. McPhee
Molecules 2015, 20(7), 13374-13383; https://doi.org/10.3390/molecules200713374
Received: 27 May 2015 / Revised: 27 June 2015 / Accepted: 30 June 2015 / Published: 22 July 2015
(This article belongs to the Section Medicinal Chemistry)
Control of postprandial hyperglycemia is crucial in the management of diabetes mellitus. Despite the use of the current hypoglycemic drugs, incidence of diabetes and related diseases continue to increase. This study aimed at evaluating the in vivo antihyperglycemic activity of methyl-3β-hydroxylanosta-9,24-dien-21-oate (RA-3), a lanosteryl triterpene isolated, and characterized from Protorhus longifolia stem bark. Spectroscopic data analysis was used to establish and verify the structure of the triterpene. The antihyperglycemic activity of the triterpene was evaluated in an STZ-induced diabetes rat model. The experimental animals were orally administered with RA-3 (100 mg/kg body weight) daily for 14 days. An oral glucose tolerance test was also performed. The animals were euthanized and biochemical analysis of antioxidant status, some glycolytic enzymes and glycogen content were conducted on serum and liver samples, respectively. RA-3 exhibited hypoglycemic activity by reducing blood glucose levels by 37%. The triterpene also improved glucose tolerance in the diabetic rats. Relatively higher hepatic glycogen content, hexokinase and glucokinase activity with a decrease in glucose-6-phosphatase activity were observed in the triterpene-treated diabetic group when compared with the diabetic control group. The triterpene treatment further increased antioxidant status of the diabetic animals; increased activity of superoxide dismutase and catalase were observed along with a decrease in malondialdehyde content. The results indicate potential pharmaceutical effects of lanosteryl triterpene in the management of diabetes mellitus. View Full-Text
Keywords: triterpene; antihyperglycemic activity; antioxidant status triterpene; antihyperglycemic activity; antioxidant status
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Mosa, R.A.; Cele, N.D.; Mabhida, S.E.; Shabalala, S.C.; Penduka, D.; Opoku, A.R. In Vivo Antihyperglycemic Activity of a Lanosteryl Triterpene from Protorhus longifolia. Molecules 2015, 20, 13374-13383.

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