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Open AccessArticle

7-Epiclusianone, a Benzophenone Extracted from Garcinia brasiliensis (Clusiaceae), Induces Cell Cycle Arrest in G1/S Transition in A549 Cells

1
Institute of Biomedical Sciences, Federal University of Alfenas, 37130-000 Alfenas, Brazil
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Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of Sao Paulo, 05508-000 São Paulo, Brazil
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Institute of Chemistry, Federal University of Alfenas, 37130-000 Alfenas, Brazil
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Institute of Environmental, Chemical and Pharmaceutical Sciences, Federal University of Sao Paulo, 09920-000 Diadema, Brazil
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Institute of Chemistry, Federal University of Viçosa, 36570-900 Viçosa, Brazil
*
Author to whom correspondence should be addressed.
Academic Editor: Fernando Albericio
Molecules 2015, 20(7), 12804-12816; https://doi.org/10.3390/molecules200712804
Received: 16 May 2015 / Revised: 23 June 2015 / Accepted: 8 July 2015 / Published: 15 July 2015
(This article belongs to the Section Natural Products Chemistry)
Lung cancer is the leading cause of cancer deaths in the world. Disease stage is the most relevant factor influencing mortality. Unfortunately, most patients are still diagnosed at an advanced stage and their five-year survival rate is only 4%. Thus, it is relevant to identify novel drugs that can improve the treatment options for lung cancer. Natural products have been an important source for the discovery of new compounds with pharmacological potential including antineoplastic agents. We have previously isolated a prenylated benzophenone (7-epiclusianone) from Garcinia brasiliensis (Clusiaceae) that has several biological properties including antiproliferative activity against cancer cell lines. In continuation with our studies, the present work aimed to investigate the mechanisms involved with antiproliferative activity of 7-epiclusianone in A549 cells. Our data showed that 7-epiclusianone reduced the viability of A549 cells in a concentration-dependent manner (IC50 of 16.13 ± 1.12 μM). Cells were arrested in G1/S transition and apoptosis was induced. In addition, we observed morphological changes with cytoskeleton disorganization in consequence of the treatment. Taken together, the results showed that cell cycle arrest in G1/S transition is the main mechanism involved with antiproliferative activity of 7-epiclusianone. Our results are promising and open up the prospect of using this compound in further anticancer in vivo studies. View Full-Text
Keywords: 7-epiclusianone; Garcinia brasiliensis; antiproliferative activity; lung cancer; cell cycle arrest; cell death 7-epiclusianone; Garcinia brasiliensis; antiproliferative activity; lung cancer; cell cycle arrest; cell death
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Ionta, M.; Ferreira-Silva, G.A.; Niero, E.L.; Costa, É.D.; Martens, A.A.; Rosa, W.; Soares, M.G.; Machado-Santelli, G.M.; Lago, J.H.G.; Santos, M.H. 7-Epiclusianone, a Benzophenone Extracted from Garcinia brasiliensis (Clusiaceae), Induces Cell Cycle Arrest in G1/S Transition in A549 Cells. Molecules 2015, 20, 12804-12816.

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