Mimicking the Lipid Peroxidation Inhibitory Activity of Phospholipid Hydroperoxide Glutathione Peroxidase (GPx4) by Using Fatty Acid Conjugates of a Water-Soluble Selenolane
Abstract
:1. Introduction
2. Results and Discussion
2.1. Synthesis of DHS-Fatty Acid Conjugates 2
2.2. Lipid Peroxidation Assay Using Lecithin/Cholesterol Liposome
2.3. Colony Formation Assay
2.4. Antioxidant Function as Possible GPx4 Mimics
3. Experimental Section
3.1. General Information
3.2. Synthesis of DHS-Fatty Acid Conjugates 2a–l
3.3. Lipid Peroxidation Assay
3.4. Colony Formation Assay
4. Conclusions
Supplementary Materials
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Iwaoka, M.; Katakura, A.; Mishima, J.; Ishihara, Y.; Kunwar, A.; Priyadarsini, K.I. Mimicking the Lipid Peroxidation Inhibitory Activity of Phospholipid Hydroperoxide Glutathione Peroxidase (GPx4) by Using Fatty Acid Conjugates of a Water-Soluble Selenolane. Molecules 2015, 20, 12364-12375. https://doi.org/10.3390/molecules200712364
Iwaoka M, Katakura A, Mishima J, Ishihara Y, Kunwar A, Priyadarsini KI. Mimicking the Lipid Peroxidation Inhibitory Activity of Phospholipid Hydroperoxide Glutathione Peroxidase (GPx4) by Using Fatty Acid Conjugates of a Water-Soluble Selenolane. Molecules. 2015; 20(7):12364-12375. https://doi.org/10.3390/molecules200712364
Chicago/Turabian StyleIwaoka, Michio, Arisa Katakura, Jun Mishima, Yoshimi Ishihara, Amit Kunwar, and Kavirayani Indira Priyadarsini. 2015. "Mimicking the Lipid Peroxidation Inhibitory Activity of Phospholipid Hydroperoxide Glutathione Peroxidase (GPx4) by Using Fatty Acid Conjugates of a Water-Soluble Selenolane" Molecules 20, no. 7: 12364-12375. https://doi.org/10.3390/molecules200712364