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Molecules 2015, 20(5), 9263-9294;

Recent Advances in Click Chemistry Applied to Dendrimer Synthesis

Chimie, Université Laval, 1045 avenue de la Médecine, Pavillon Alexandre-Vachon, QC G1V 0A6, Canada
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editor: Arnaud Gautier
Received: 16 April 2015 / Accepted: 12 May 2015 / Published: 20 May 2015
(This article belongs to the Collection Advances in Click Chemistry)
Full-Text   |   PDF [1497 KB, uploaded 20 May 2015]   |  


Dendrimers are monodisperse polymers grown in a fractal manner from a central point. They are poised to become the cornerstone of nanoscale devices in several fields, ranging from biomedicine to light-harvesting. Technical difficulties in obtaining these molecules has slowed their transfer from academia to industry. In 2001, the arrival of the “click chemistry” concept gave the field a major boost. The flagship reaction, a modified Hüisgen cycloaddition, allowed researchers greater freedom in designing and building dendrimers. In the last five years, advances in click chemistry saw a wider use of other click reactions and a notable increase in the complexity of the reported structures. This review covers key developments in the click chemistry field applied to dendrimer synthesis from 2010 to 2015. Even though this is an expert review, basic notions and references have been included to help newcomers to the field. View Full-Text
Keywords: dendrimer; dendron; click; Hüisgen cycloaddition; thiol-ene; thiol-yne; Diels-Alder dendrimer; dendron; click; Hüisgen cycloaddition; thiol-ene; thiol-yne; Diels-Alder

Figure 1

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Arseneault, M.; Wafer, C.; Morin, J.-F. Recent Advances in Click Chemistry Applied to Dendrimer Synthesis. Molecules 2015, 20, 9263-9294.

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