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Open AccessCommunication

Inhibitory Effects of Verrucarin A on Tunicamycin-Induced ER Stress in FaO Rat Liver Cells

1
LINC Project Group, Daejeon University, Daejeon 300-716, Korea
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Department of Chemistry, Mokwon University, Daejeon 302-729, Korea
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Soram Korean Medicine Hospital, M-Tower, Gangnam-Gu, Seoul 135-879, Korea
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Soram Bio-Medicine Research Institute (SBRI), Soram Korean Medicine Hospital, M-Tower, Gangnam-Gu, Seoul 135-879, Korea
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Chemical Biology Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Yeongudanjiro, Ochang, Cheongwon, Chungbuk 363-883, Korea
6
Hyehwa-Liberal Arts College, Daejeon University, Daejeon 300-716, Korea
*
Authors to whom correspondence should be addressed.
Academic Editor: Isabel C. F. R. Ferreira
Molecules 2015, 20(5), 8988-8996; https://doi.org/10.3390/molecules20058988
Received: 2 April 2015 / Revised: 2 May 2015 / Accepted: 13 May 2015 / Published: 19 May 2015
(This article belongs to the Collection Bioactive Compounds)
Endoplasmic reticulum (ER) stress is linked with development and maintenance of cancer, and serves as a therapeutic target for treatment of cancer. Verrucarin A, isolated from the broth of Fusarium sp. F060190, showed potential inhibitory activity on tunicamycin-induced ER stress in FaO rat liver cells. In addition, the compound decreased tunicamycin-induced GRP78 promoter activity in a dose dependent manner without inducing significant inhibition of luciferase activity and cell growth for 6 and 12 h. Moreover, the compound decreased the expression of GRP78, CHOP, XBP-1, and suppressed XBP-1, and reduced phosphorylation of IRE1α in FaO rat liver cells. This evidence suggests for the first time that verrucarin A inhibited tunicamycin-induced ER stress in FaO rat liver cells. View Full-Text
Keywords: verrucarin A; Fusarium sp. F060190; tunicamycin; ER stress; FaO rat liver cells verrucarin A; Fusarium sp. F060190; tunicamycin; ER stress; FaO rat liver cells
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Bae, E.Y.; Lee, S.W.; Seong, S.; Cho, W.; Ahn, J.S.; Cho, H.-S. Inhibitory Effects of Verrucarin A on Tunicamycin-Induced ER Stress in FaO Rat Liver Cells. Molecules 2015, 20, 8988-8996.

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